Euro
USD
British Pound
NULL
Product Description
Histone H4 (Mono-Methyl K20) polyclonal Antibody | BS8449 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse,Rat,Other (Wide Range)
Application: WB,IHC,IF
Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Background: Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination. These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Histone H4 (Mono-Methyl K20) polyclonal Antibody detects endogenous levels of histone H4 only when Mono-Methyled at Lys20.
Molecular Weight: ~ 11 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: H4K20me1
Immunogen: Synthetic peptide conjugated to KLH derived from within residues 1-100 of Human Histone H4, Mono-methylated at K20.
Conjugate: Unconjugated
Modification: Methylated
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Examples of Crosstalk Between Post-translational Modifications,
