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Product Description
PFKFB3 polyclonal Antibody | BS91059 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB,IHC
Application Range: WB 1:2000 - 1:5000 IHC 1:50 - 1:200
Background: Among the enzymes playing role in glycolysis,four allosteric PFKFB enzymes 1–4 expressed by four independent PFKFB genes, catalyze the rate-limiting phosphorylation of fructose-6-phosphate to fructose-1, 6-bisphosphate, using ATP as the energy source in the glycolysis pathway. Among these four allosteric enzymes, PFKFB3 enzyme retains the highest Kinase/Biphosphatase activity ratio and is expressed by PFKFB3 gene which has been demonstrated to be highly expressed in leukemic cells and in solid tumors. Moreover, mitogenic, hypoxic and inflammatory conditions have an inductive effect on the expression of PFKFB3. Hence upregulation of PFKFB genes specific to cancer cells compared to their normal counterparts (from the same patients) with more robust over-expression in breast and lung cancer make it a more appropriate target.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: PFKFB3 polyclonal Antibody detects endogenous levels of PFKFB3 protein.
Molecular Weight: 0
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: 6PF-2-K/Fru-2, 6-P2ase 3, PFK/FBPase 3, PFKFB3, 6 phosphofructo 2 kinase/ fructose 2, 6 bisphosphatase, 6 phosphofructo 2 kinase/fructose 2, 6 biphosphatase 3, 6-bisphosphatase, 6-P2ase 3, 6-P2ASE brain/placenta-type isozyme, 6PF 2 K/Fru 2, 6 P2ASE brain/placenta type isozyme, 6PF 2-K/Fru 2, 6 P2ase 3, 6PF-2-K/Fru-2, F263, fructose 6 phosphate, 2 kinase/fructose 2, 6 bisphosphatase, Fructose-2, Inducible 6 phosphofructo 2 kinase/fructose 2, 6 bisphosphatase, iPFK 2, iPFK-2, IPFK2, PFK/FBPase 3, PFK2, PFKFB3, Renal carcinoma antigen NY REN 56, Renal carcinoma antigen NY-REN-56, uPFK 2,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
