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Product Description
Cdk8 polyclonal Antibody | BS90286 | Bioworld
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB IP
Application Range: WB:1:1,000-1:2,000
Background: Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks) . Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. Large complexes containing Cdk8, cyclin C and the large subunit of RNA polymerase II have been identified. Cdk8 is thought to regulate RNA polymerase II function in conjunction with cyclin C. Cdk8 has been demonstrated to function as a transcriptional activator when fused to the DNA binding domain of GAL4.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Cdk8 polyclonal Antibody detects endogenous levels of Cdk8 protein.
Molecular Weight: 53 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CDK8, cdk8, CDK8 protein kinase, CDK8, Cell Division Kinase 8, Cell division protein kinase 8, Cyclin Dependent kinase 8, Cyclin-dependent kinase 8, K35, Mediator complex subunit cdk8, Mediator of RNA polymerase II transcription subunit cdk8, Protein kinase K35,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway:
