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Biovision

  • SQ 22536

    Biovision | SQ 22536 | 2019

    Cell-permeable. SQ 22,536 is an adenylyl cyclase inhibitor. (IC₅₀ = 1.4 μM). It inhibits cAMP production induced by prostaglandin E1 in platelet lysates (IC₅₀ = 82 µM) and in intact platelets (IC₅₀ =...

    €960 - €2,952
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  • SPDP Crosslinker

    Biovision | SPDP Crosslinker | 2328

    KEY FEATURES: • SPDP contains a dithiopyridyl group which is reactive towards cysteines (-SH groups) and an NHS group, which is useful when targeting primary amines (-NH2 groups) • SPDP releases a...

    €909 - €2,730
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  • SP-2509

    Biovision | SP-2509 | 9446

    SP-2509 is a reversible inhibitor of Lysine-specific demethylase (LSD1) (IC₅₀ = 13 nM). It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to CoREST, allowing...

    €717 - €2,091
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  • Sodium Oxamate

    Biovision | Sodium Oxamate | 2580

    Oxamate is a known glycolysis inhibitor with its target being lactate dehydrogenase (LDH).Oxamate is a known glycolysis inhibitor with its target being lactate dehydrogenase (LDH).Biovision | 2580 |...

    €615 - €1,599
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  • SNX-2112

    Biovision | SNX-2112 | B2211

    SNX-2112 is a potent heat-shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. SNX-2112 selectively accumulates in tumors compared to normal tissues and binds to the N-terminal...

    €864 - €2,682
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  • SNAP-37889

    Biovision | SNAP-37889 | B2388

    SNAP-37889 is a galanin-3 receptor (GAL3) antagonist. Reduces ethanol self-administration and cue-induced re-instatement in alcohol-preferring (iP) rats with no alterations in locomotor activity or...

    €615 - €1,701
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  • Smo Antagonist, SA9

    Biovision | Smo Antagonist, SA9 | 2155

    SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia...

    €642 - €1,134
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  • Smo Agonist, SAG

    Biovision | Smo Agonist, SAG | 1939

    Cell-permeable. A Smoothened (Smo) agonist that has shown to induce Hedgehog pathway activation and counteract cyclopamine inhibition of Smo. SAG has been reported to act as an activator at low...

    €813 - €2,484
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  • SMER-3

    Biovision | SMER-3 | 2514

    SMER-3 (Small molecule enhancer of rapamycin -3) is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes that results...

    €1,011 - €2,583
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  • SL0101

    Biovision | SL0101 | B1895

    SL0101 is a potent and selective inhibitor of ribosomal S6 kinase (RSK) (IC₅₀ = 89 nM for RSK2). Does not have any effect on upstream kinases such as MEK, Raf and PKC. Inhibits the growth of MCF-7...

    €1,062 - €3,444
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  • SKPin C1

    Biovision | SKPin C1 | 2343

    Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes...

    €666 - €1,917
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  • SKLB610

    Biovision | SKLB610 | 2610

    SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibits angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and...

    €666 - €1,893
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  • SirtACt

    Biovision | SirtACt | 2741

    SirtAct is a potent Sirtuin 1 (SIRT1) activator. It increases fluorescence by 233% in a SIRT1 activity assay. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in...

    €717 - €2,091
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  • SIRT2 Inhibitor

    Biovision | SIRT2 Inhibitor | 1857

    Brain- permeable. A potent and selective sirtuin 2 deacetylase (SIRT2) inhibitor. Reduces neuronal cholesterol by inhibiting SIRT2 activity.SIRT2 inhibitor is a brain-permeable, potent and selective...

    €693 - €1,995
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  • Shz-1

    Biovision | Shz-1 | 1915

    Cell-permeable. A sulfonylhydrazone (Shz) small molecule that acts as an enhancer of myocardial regenerative repair by stem cells. Potently induces Nkx2.5 and a subset of other cardiac markers,...

    €642 - €1,503
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  • SF-2523

    Biovision | SF-2523 | B1858

    SF-2523 is a potent and highly selective inhibitor of PI3K and BRD4 with IC₅₀ values of 16 and 241 nM for PI3Kα and BD1, respectively.SF-2523 is a potent and highly selective inhibitor of PI3K and...

    €666 - €1,893
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  • SD208

    Biovision | SD208 | 2885

    SD208 is a potent, ATP-competitive transforming growth factor-β receptor 1 (TGF-βR1) kinase inhibitor (IC₅₀ = 49 nM). Displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common...

    €909 - €2,877
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  • SCR7 pyrazine

    Biovision | SCR7 pyrazine | B1119

    SCR7 pyrazine is a potent inhibitor of nonhomologous endjoining (NHEJ) mediated by DNA ligase IV. Enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency in vitro.SCR7 pyrazine is a...

    €717 - €2,091
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  • Sclerotiorin

    Biovision | Sclerotiorin | 2334

    An antibiotic Isolated from fungus Penicillium sp. Cholesteryl ester transfer protein (CETP) activity inhibitor (IC₅₀ = 19.4 µM). Weak antagonist of human endothelin receptor A (ETA) and B (ETB). A...

    €570 - €1,554
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  • SCH-58261

    Biovision | SCH-58261 | B1638

    SCH-58261 is the adenosine (A2A) receptor competitive antagonist. Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.SCH-58261 is the adenosine (A2A) receptor...

    €666 - €1,797
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  • SCH-529704

    Biovision | SCH-529704 | 9438

    SCH-529074 is a small molecule activator of mutant p53. It binds specifically to the p53 DBD (DNA binding domain) in a saturable manner with an affinity of 1-2 µM. Binding restores wild type function...

    €1,011 - €3,174
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  • SC-79

    Biovision | SC-79 | 2766

    SC-79 is an Akt activator. Binds to the pleckstrin homology (PH) domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. Enhances Akt phosphorylation by...

    €615 - €1,158
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  • SC-26196

    Biovision | SC-26196 | B1580

    SC-26196 is a selective Δ6 desaturase inhibitor (IC₅₀ = 0.2 μM in vitro. It displays selectivity over Δ5 and Δ9 desaturases (IC₅₀ values are >200 μM in vitro). Exhibits anti-inflammatory properties...

    €909 - €2,877
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  • SBHA

    Biovision | SBHA | 2202

    SBHA is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC₅₀ = 0.25 μM) and HDAC3 (IC₅₀ = 0.30 μM). SBHA causes cell differentiation, cell cycle arrest, or...

    €546 - €1,254
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  • SB-742457

    Biovision | SB-742457 | 9568

    SB-742457 is a highly selective 5-HT6 receptor antagonist with potential cognition, memory and learning-enhancing effects; displays >100-fold selectivity over other receptors. in anxiolytic and...

    €813 - €2,484
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  • SB-715992

    Biovision | SB-715992 | 2468

    A potent, reversible, small molecule inhibitor of kinesin spindle protein (KSP), a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through...

    €1,011 - €3,174
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  • SB-525334

    Biovision | SB-525334 | 2880

    SB-525334 is a potent and selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC₅₀ = 14.3 nM); displays 4-fold less potency against ALK4 (IC₅₀ = 58.5 nM) and inactive as...

    €909 - €2,877
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  • SB-415286

    Biovision | SB-415286 | B1954

    SB-415286 is a potent, selective and ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α). Displays minimal activity against 24 other protein kinases (IC₅₀ > 10 μ M)...

    €1,062 - €3,444
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  • SB-242235

    Biovision | SB-242235 | B2273

    SB-242235 is a potent and selective p38 MAP kinase inhibitor (IC₅₀ = 1.0 uM).SB-242235 is a potent and selective p38 MAP kinase inhibitor (IC₅₀ = 1.0 uM).Biovision | B2273 | SB-242235...

    €813 - €2,337
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  • SB239063

    Biovision | SB239063 | B1699

    SB239063 is a potent and selective p38 MAPK inhibitor with an IC50 of 44 nM against p38α MAPK while exhibited no activity against the γ- and δ-kinase isoforms.SB239063 is a potent and selective p38...

    €813 - €2,484
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  • SB 939

    Biovision | SB 939 | 2285

    An orally available pan-histone deacetylase (HDAC) inhibitor binding all HDAC isozymes with similar affinity (Kis = 16-28 nM) with the exception of HDAC6 and 7 (Kis = 247 and 104 nM, respectively)...

    €570 - €1,503
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  • Sauchinone

    Biovision | Sauchinone | 2312

    Isolated from Saururus chinensis. Displays cytoprotective and antioxidant activities in cultured hepatocytes. Suppresses NF-kB p65 activity. Neuroprotective. Bone resorption/osteoclastogenesis...

    €570 - €1,503
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  • SATA

    Biovision | SATA | 2363

    A protein modification reagent used to convert primary amine groups into protected sulfhydryls (-SH). The sulfhydryl is readily made available for use in subsequent reactions by treatment with...

    €717 - €3,321
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