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  • Compound 401

    Biovision | Compound 401 | 1657

    Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC₅₀ = 0.28 µM) that also targets mTOR (IC₅₀ = 5. 3µM), but not PI 3-K in vitro. Induces apoptosis in...

    $1,281
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  • Tenovin-3

    Biovision | Tenovin-3 | B1828

    Tenovin-3 is a p53 activator and an inhibitor of SIRT2.Tenovin-3 is a p53 activator and an inhibitor of SIRT2.Biovision | B1828 | Tenovin-3 DataSheetAlternate Name/Synonyms:...

    $949 - $2,870
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  • WZB117

    Biovision | WZB117 | B1573

    WZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibits cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC₅₀ of approximately 10 μM.WZB117 is an...

    $1,008 - $3,129
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  • DASA-58

    Biovision | DASA-58 | B2163

    DASA-58 is a selective activator of pyruvate kinase M2 (PKM2) (AC₅₀ = 38 nM). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated...

    $718 - $1,985
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  • ACY-775

    Biovision | ACY-775 | B2011

    ACY-775 is a potent and selective HDAC6 inhibitor (IC₅₀ = 7.5 nM). Displays antidepressant-like properties.ACY-775 is a potent and selective HDAC6 inhibitor (IC₅₀ = 7.5 nM). Displays...

    $1,180 - $3,703
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  • ITE

    Biovision | ITE | B1579

    ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). It enhances differentiation of cancer stem-like cells detected by the decrease of sphere formation and proliferation from...

    $1,239 - $4,018
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  • LLY-507

    Biovision | LLY-507 | B1111

    LLY-507 is a potent, cell-permeable, small molecule inhibitor of SMYD2 (IC₅₀ = 15 nM), a lysine N-methyltransferase. It has been shown to inhibit p53 lysine monomethylation in KYSE-150 esophageal...

    $718 - $1,985
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  • 3-Methyladenine

    Biovision | 3-Methyladenine | 2249

    Commonly used as a specific inhibitor of autophagic sequestration. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K)...

    $606 - $1,351
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  • LMK-235

    Biovision | LMK-235 | B1642

    LMK235 is a HDAC inhibitor, previously shown to be a novel and specific inhibitor of human HDAC4 and 5, with IC50 values of 0.49 μM (A2780) and 0.32 μM (A2780 CisR).LMK235 is a HDAC inhibitor,...

    $809 - $2,125
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  • GSK180736A

    Biovision | GSK180736A | B1628

    GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.Biovision |...

    $865 - $2,587
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  • Calyculin A

    Biovision | Calyculin A | 1562

    Calyculin A is a very potent inhibitor (Ki = 0.1 nM) with high specificity for the PP-1 and PP-2 classes of protein serine/threonine phosphatase. It is also a potent non-phorbol type tumor promoter...

    $1,292
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  • Anisomycin

    Biovision | Anisomycin | 1549

    An activator of p54 and MAP kinases. Synergistic with growth factors and phorbol esters to superinduce cFas and c-Jun, by acting as a potent signaling agonist. Induces apoptosis in the human...

    $865
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  • PF-04418948

    Biovision | PF-04418948 | B1168

    PF-04418948 is a potent EP2 receptor antagonist with an IC₅₀ of 16 nM for human EP2 receptors. It also displays greater selectivity for EP2 receptors over EP1, 3, 4, DPI and CRTH2 receptors. It...

    $837 - $2,440
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  • TAS-301

    Biovision | TAS-301 | 9644

    TAS-301 is an inhibitor of smooth muscle cell migration and proliferation. Blocks voltage-independent calcium influx and downstream PKC signaling. Inhibits neointimal thickening after balloon...

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  • AMI-1

    Biovision | AMI-1 | 1943

    Cell-permeable. A potent and specific protein arginine N-methyltransferase (PRMTs) inhibitor (IC₅₀ = 8.8 μM for human PRMT1 and 3.0 μM for yeast Hmt1p ). Does not compete for the AdoMet...

    $921 - $2,811
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  • BI-847325

    Biovision | BI-847325 | B1589

    BI-847325 is an ATP-competitive dual inhibitor of MEK and Aurora kinases. Potent inhibition of MEK1/2 and Aurora A/B kinases by BI-847325 was demonstrated in enzymatic and cellular assays.BI-847325...

    $1,292 - $4,277
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  • NMS-P118

    Biovision | NMS-P118 | B2320

    A potent, and selective poly(ADP-ribose) polymerase 1 (PARP1) inhibitor. It is selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM). NMS-P118 displays anticancer activity as single agent, as...

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  • Selonsertib

    Biovision | Selonsertib | B1312

    Selonsertib is a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the...

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  • DEL-22379

    Biovision | DEL-22379 | B1680

    DEL-22379 is an ERK dimerization inhibitor with IC50 of 0.5 μM.DEL-22379 is an ERK dimerization inhibitor with IC50 of 0.5 μM.Biovision | B1680 | DEL-22379 DataSheetAlternate Name/Synonyms:...

    $1,092 - $3,413
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  • KC7F2

    Biovision | KC7F2 | 9641

    KC7F2 is a small molecule HIF-1 pathway inhibitor that inhibits HIF-1α protein translation, but not transcription. It inhibits hypoxia-induced expression of several HIF target genes, such as carbonic...

    $837 - $2,440
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  • BQR-695

    Biovision | BQR-695 | B2078

    BQR-695 is a potent and selective PI4K inhibitor. Displays potency against both human PI4KIIIβ and Plasmodium falciparum asexual blood stages (IC₅₀ values of 90 nM and 71 nM, respectively)...

    $1,180 - $3,875
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  • VR23

    Biovision | VR23 | B1515

    VR23 is a potent and selective inhibitor of trypsin-like proteasomes (IC₅₀ = 1 nmol/L), chymotrypsin-like proteasomes (IC₅₀ = 50-100 nmol/L), and caspase-like proteasomes (IC₅₀ = 3 μmol/L). The main...

    $1,061 - $3,357
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  • L-NMMA acetate

    Biovision | L-NMMA acetate | 2348

    A competitive, irreversible and non-selective inhibitor of all three NOS isoforms. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively...

    $637 - $2,156
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  • STF-31

    Biovision | STF-31 | 9585

    STF-31 is a potent glucose transporter 1 (GLUT1) inhibitor (IC₅₀ = ~ 1 µM). It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress GLUT1...

    $949 - $2,898
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  • Endoxifen

    Biovision | Endoxifen | 9614

    Endoxifen is the metabolite of Tamoxifen (Cat. No.1551) and Estrogen receptor α (ERα) ligand. Endoxifen is responsible for the effectiveness of tamoxifen in ER-positive breast cancer. Potent...

    $1,239 - $4,018
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  • BRD7116

    Biovision | BRD7116 | B1578

    BRD 7116 is a selective inhibitor of leukemia stem cell (LSC) activity (EC₅₀ value of 200 nM). BRD 7116 does not affect normal hematopoietic stem cells or AML cell lines (EC₅₀s = 20 µM).BRD 7116 is a...

    $1,239 - $4,018
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  • Targocil

    Biovision | Targocil | B2247

    Targocil is a novel antibiotic that inhibits a late acting step in the WTA (Wall teichoic acid) pathway. WTAs are phosphate-rich, sugar-based polymers attached to the cell walls of most Gram-positive...

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  • CIQ

    Biovision | CIQ | B2005

    CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. Increases channel opening efficiency and enhances NMDA receptor responses.CIQ is a subunit-selective...

    $949 - $2,727
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  • PU-WS13

    Biovision | PU-WS13 | 9442

    PU-WS13 is a potent, Grp94-specific Hsp90 inhibitor of the purine scaffold class. PU-WS13 has been shown to reduce the viability of breast cancer cells that express high levels of cell surface HER2...

    $1,239 - $3,875
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  • GSK-5959

    Biovision | GSK-5959 | B2343

    GSK-5959 is a potent and selective BRPF1 (BR140 or Peregrin) bromodomain inhibitor (IC₅₀ = 80 nM). GSK-5959 displays >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains. BRPF1...

    $777 - $2,209
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  • PFI-4

    Biovision | PFI-4 | B2330

    PFI-4 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Displays >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. BRPF1...

    $949 - $2,898
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  • TEPP-46

    Biovision | TEPP-46 | B2164

    TEPP-46 (ML-265) is a potent and selective PKM2 activator. TEPP-46 activates tumor-specific PKM2 (EC₅₀ = 92 nM) by binding to the dimer-dimer interface between two subunits of PKM2 and inducing...

    $718 - $1,985
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  • CWHM-12

    Biovision | CWHM-12 | B1251

    CWHM-12 a potent small molecule inhibitor of αV integrins with IC₅₀s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8. It displays less potency on αvβ5 (IC₅₀ = 61 nM) and on inhibition on αIIbβ3/α2β1/α10β1...

    $1,180 - $3,703
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  • LDN-57444

    Biovision | LDN-57444 | 2016

    Cell-permeable. LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins...

    $718 - $1,985
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  • UMI-77

    Biovision | UMI-77 | B1108

    UMI-77 is a novel, selective, Mcl-1 SMI inhibitor. UMI-77 is selective for Mcl-1 over other members of the antiapoptotic Bcl-2 family with a Ki of 490 nM. UMI-77 acts by binding to the BH3-binding...

    $949 - $2,898
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  • PFI-2

    Biovision | PFI-2 | B1259

    PFI-2 is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor (IC₅₀ ~2 nM). It has > 100-fold selectivity over other methyltransferases and other non-epigenetic targets...

    $949 - $2,898
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  • FIIN-2

    Biovision | FIIN-2 | 9577

    FIIN-2 is a potent, selective, irreversible, next-generation covalent FGFR inhibitor. FIIN-2 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper...

    $1,061 - $3,357
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  • AA26-9

    Biovision | AA26-9 | B2159

    AA26-9 is a potent and broad-spectrum serine hydrolase inhibitorAA26-9 is a potent and broad-spectrum serine hydrolase inhibitorBiovision | B2159 | AA26-9 DataSheetAlternate Name/Synonyms:...

    $1,120 - $3,584
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  • Bioymifi

    Biovision | Bioymifi | 9424

    Bioymifi is a potent and selective death receptor 5 (DR5) activator. Bioymifi works by mimicking the ability of TRAIL, the natural DR5 ligand, to stimulate clustering of DR5, triggering apoptosis...

    $949 - $2,898
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  • TMP269

    Biovision | TMP269 | 2679

    TMP269 is a potent, selective and cell-permeable class IIa HDAC inhibitor (IC₅₀ values of of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively). Displays 20-400 fold...

    $1,008 - $3,014
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  • BMS-3

    Biovision | BMS-3 | B2298

    BMS-3 is a potent and specific inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC₅₀s = 5 and 6 nM, respectively). LIMK1 is responsible for the inactivation of cofilin (ADF family protein),...

    $837 - $2,440
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  • AMG-47a

    Biovision | AMG-47a | 2825

    AMG-47a is a potent inhibitor of Lck and T cell proliferation. It exhibits anti-inflammatory activity (ED₅₀ = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. In several other in vitro...

    $1,239 - $3,987
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  • Filgotinib

    Biovision | Filgotinib | 2871

    Filgotinib (GLPG0634) is a potent and selective JAK1 inhibitor; displays >30-fold selectivity for JAk1 over JAK2. GLPG0634 dose-dependently inhibits Th1 and Th2 differentiation and to a lesser extent...

    $1,120 - $3,584
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  • Valsartan

    Biovision | Valsartan | 2004

    Cell-permeable. A high affinity angiotensin I receptor antagonist (Ki = 2.38 nM). Clinically useful antihypertensive agent. Active in vivo. Also, a recent study has shown that Valsartan lowers brain...

    $809 - $6,167
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  • CCT244747

    Biovision | CCT244747 | 9575

    CCT244747 is a potent, selective and ATP-competitive CHK1 inhibitor. CCT244747 inhibits cellular CHK1 activity (IC₅₀ = 29-170 nmol/L), significantly enhances the cytotoxicity of several anticancer...

    $1,292 - $4,277
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  • CX-6258

    Biovision | CX-6258 | 2851

    CX-6258 is a potent pan-Pim kinases inhibitor (IC₅₀ values of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively). CX-6258 exhibits in vitro synergy with chemotherapeutics and robust in...

    $837 - $2,440
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  • TCS PIM-1 1

    Biovision | TCS PIM-1 1 | 2848

    TCS PIM-1 1 is a potent, ATP-competitive Pim-1 kinase inhibitor (IC₅₀ = 50 nM). Displays high selectivity over Pim-2 and MEK1/2 (IC₅₀ >20 µM).TCS PIM-1 1 is a potent, ATP-competitive Pim-1 kinase...

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  • AGI-5198

    Biovision | AGI-5198 | 2369

    A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1). AGI-5198 inhibits IDH1 R132H and R132C mutants in vitro with IC₅₀ values of 0.07 and 0.16 µM, respectively, but not...

    $777 - $2,156
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  • RN486

    Biovision | RN486 | 9678

    RN486 is a potent Bruton's tyrosine kinase (Btk) inhibitor (IC₅₀ = 4 nM). When tested with human Ramos B cells or whole blood, RN486 treatment reduces the expression of CD69/B cells proliferation and...

    $718 - $1,894
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  • LFM-A13

    Biovision | LFM-A13 | 2414

    FM-A13 is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC₅₀’s = 2.5 µM (recombinant BTK) and 17.2 µM (human BTK). It has also been shown to inhibit Polo-like kinase (PLK) (IC₅₀ = 61 µM...

    $837 - $2,440
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