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Biovision

  • PS-1145

    Biovision | PS-1145 | 9671

    PS-1145 is a potent and selective IκB kinase (IKK) inhibitor (IC₅₀ = 100 nM). Has no effect on PKA, PKC and CKII activity. PS-1145 efficiently inhibits both basal and induced NF-κB activity in PC...

    $1,120 - $3,584
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  • Glecaprevir

    Biovision | Glecaprevir | B2347

    Glecaprevir is a hepatitis C virus nonstructural protein 3/4A protease inhibitor that targets the viral RNA replication.Glecaprevir is a hepatitis C virus nonstructural protein 3/4A protease...

    $1,239 - $4,018
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  • Ezutromid

    Biovision | Ezutromid | B1248

    Ezutromid is a first orally available drug for the treatment of Duchenne muscular dystrophy (DMD), a lethal, X-linked muscle wasting disease caused due to lack of dystrophin-a cytoskeleton protein...

    $1,008 - $3,129
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  • Acalabrutinib

    Biovision | Acalabrutinib | B1193

    Acalabrutinib (ACP-196) is an orally available, selective irreversible inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. It is a second generation BTK inhibitor with...

    $837 - $2,440
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  • Solithromycin

    Biovision | Solithromycin | B1222

    Solithromycin (CEM-101) is a "fourth-generation" macrolide antibiotic, that has three binding sites and is acid stable. The three binding sites confer activity against bacteria resistant to the older...

    $1,239 - $4,018
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  • Fidaxomicin

    Biovision | Fidaxomicin | 2832

    Fidaxomycin is a natural macrocyclic antibiotic and RNA polymerase inhibitor that displays selectivity for Gram-positive bacteria over Gram-negative bacteria (IC₅₀s = 0.4 and 6 μM, respectively). It...

    $1,120 - $3,584
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  • Actinomycin D

    Biovision | Actinomycin D | 1036

    An antineoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and...

    $802 - $3,266
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  • LGK974

    Biovision | LGK974 | 2645

    LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models,...

    $837 - $2,296
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  • ML-323

    Biovision | ML-323 | 2658

    ML323 is a potent, reversible, inhibitor of USP1-UAF1 with IC₅₀ of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and...

    $777 - $2,209
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  • ZLN005

    Biovision | ZLN005 | 2550

    ZLN005 is a small molecule transcriptional regulator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). It stimulates the expression of PGC-1α and downstream genes in skeletal...

    $665 - $1,754
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  • APY29

    Biovision | APY29 | 2591

    APY29 is a highly potent and selective allosteric modulator of IRE1α. Under endoplasmic reticulum (ER) stress, unfolded proteins accumulate in the ER to activate the ER transmembrane...

    $777 - $2,209
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  • Itraconazole

    Biovision | Itraconazole | 1987

    A synthetic broad-spectrum triazole antifungal agent with the mode of action being through Inhibition of cytochrome P450 dependent enzymes including 14α-demethylase. Recently, it has been shown that...

    $637 - $3,185
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  • Deracoxib

    Biovision | Deracoxib | B1985

    Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent and specific cyclooxygenase-2 (COX-2) inhibitor. Used in dogs to treat pain associated with osteoarthritis, or to...

    $777 - $2,209
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  • AM-095 Sodium

    Biovision | AM-095 Sodium | B1225

    AM-095 is a potent LPA1 receptor antagonist with IC₅₀ values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. In functional assays, AM-095 inhibits LPA-driven chemotaxis of CHO...

    $1,061 - $3,357
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  • Simvastatin

    Biovision | Simvastatin | 1693

    A synthetic analog of Lovastatin (Cat. No. 1692-50, 250). Cholesterol lowering drug and a competitive inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase. Inhibits the biosynthesis...

    $837 - $2,065
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  • MI-773

    Biovision | MI-773 | 9610

    MI-773, also known as SAR405838, is a spiro-oxindole that acts as a highly potent and selective MDM2 inhibitor. MI-773 binds to MDM2 with a Ki value of 0.88 nM and blocks the MDM2-p53 interaction. It...

    $777 - $1,411
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  • Embelin

    Biovision | Embelin | B1600

    An inhibitor of XIAP (X-linked inhibitor-of-apoptosis protein)An inhibitor of XIAP (X-linked inhibitor-of-apoptosis protein)Biovision | B1600 | Embelin DataSheetAlternate Name/Synonyms:...

    $1,061 - $3,357
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  • Mizoribine

    Biovision | Mizoribine | B2194

    Mizoribine is an imidazole nucleoside that acts as an immunosuppressive agent and HCV RNA replication inhibitor (IC₅₀ = 100 μM). Inhibits T and B cell proliferation. Anti-bacterial, antiviral,...

    $777 - $1,925
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  • Cilostazol

    Biovision | Cilostazol | 2393

    Cilostazol is a clinically approved phosphodiesterase III (PDE3) inhibitor (IC₅₀ = 0.2 µM) and anti-thrombotic agent. It inhibits platelet aggregation and is a direct arterial vasodilator.Cilostazol...

    $718 - $1,985
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  • Sivelestat

    Biovision | Sivelestat | B2144

    Sivelestat (ONO-5046) is a potent neutrophil elastase inhibitor. It acts as a substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC₅₀ = 19-49 nM in rat, rabbit, hamster,...

    $777 - $2,209
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  • Amprenavir

    Biovision | Amprenavir | B2141

    Amprenavir is the active metabolite of the pro-drug fosamprenavir. It acts as an antiretroviral HIV Protease Inhibitor. When used alone or in combination therapy with other antiretroviral agents,...

    $1,239 - $4,018
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  • Acyclovir

    Biovision | Acyclovir | 2200

    Acyclovir is an antiviral agent with activity against herpesvirus types 1 and 2 and varicella zoster virus. Acyclovir is converted by a herpesvirus enzyme into acyclovir triphosphate) that inhibits...

    $690 - $1,813
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  • Mevastatin

    Biovision | Mevastatin | 1694

    A HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitor. Cholesterol lowering drug. Inhibits the biosynthesis of isoprenoids; induces apoptosis by inhibition of post-translational...

    $690 - $1,754
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  • Cisplatin

    Biovision | Cisplatin | 1550

    A platinum coordination complex with potent anti-neoplastic activity.Cisplatin is a platinum coordination complex with potent anti-neoplastic activity.Biovision | 1550 | Cisplatin DataSheetAlternate...

    $837 - $2,125
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  • Carboplatin

    Biovision | Carboplatin | 1553

    An analog of Cisplatin with reduced nephrotoxicity. Displays potent anti-tumor activity.Carboplatin is an analog of Cisplatin with reduced nephrotoxicity. Displays potent anti-tumor activity...

    $921
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  • Rosiglitazone

    Biovision | Rosiglitazone | 1559

    Belongs to the thiazolidinedione class of anti-diabetic drugs. A selective ligand of PPARγ and has no PPARα-binding actionRosiglitazone belongs to the thiazolidinedione class of anti-diabetic drugs...

    $637 - $1,985
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  • Ezetimibe

    Biovision | Ezetimibe | 9468

    Ezetimibe is a cholesterol transport inhibitor. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol...

    $718 - $1,754
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  • Rofecoxib

    Biovision | Rofecoxib | B1982

    Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent cyclooxygenase-2 (COX-2) inhibitor. It displays 1,000-fold selectivity for COX-2 over that of COX-1 (IC₅₀s = 26 nM...

    $777 - $2,156
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  • Oxaliplatin

    Biovision | Oxaliplatin | 1577

    Oxaliplatin is a third-generation, diaminocyclohexane-containing platinum anti-cancer drug. The anticancer activity and the antitumor specificity of oxaliplatin mainly depend on human organic cation...

    $1,463
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  • Atazanavir

    Biovision | Atazanavir | B1901

    Atazanavir is a potent inhibitor of HIV protease (Ki of 2.66 nM). Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of...

    $949 - $2,898
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  • Dimethyl Fumarate

    Biovision | Dimethyl Fumarate | 9660

    Dimethyl fumarate is an anti-inflammatory agent. It effectively blocks NF-κB activity in multiple breast cancer cell lines and abrogates NF-κB-dependent mammosphere formation, indicating that DMF has...

    $606 - $1,411
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  • Epothilone B

    Biovision | Epothilone B | 2012

    A macrolide anticancer agent. Similar to paclitaxel (Cat. No. 1567-25), epothilone B induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to...

    $749 - $2,065
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  • Cyclopamine

    Biovision | Cyclopamine | 1578

    Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch)...

    $1,463
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  • RO8994

    Biovision | RO8994 | B1830

    RO8994 is a highly potent and selective spiroindolinone small-molecule MDM2 inhibitor, with IC₅₀ of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).RO8994 is a highly potent and...

    $1,838 - $5,996
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  • OICR-9429

    Biovision | OICR-9429 | B1256

    OICR-9429 is a small-molecule inhibitor of the WDR5-MLL interaction that effectively stops the growth of breast cancer cell lines driven by p53 gene mutation. It also stops the growth of subtype of...

    $1,008 - $3,129
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  • SR9009

    Biovision | SR9009 | B1210

    SR9009 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERB α (IC50=670 nM) and REV-ERBβ (IC50 = 800 nM). SR9009 decreases the circadian locomotor activity...

    $1,008 - $3,014
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  • EPZ011989

    Biovision | EPZ011989 | B1221

    EPZ011989 is a potent EZH2 inhibitor with Ki values that are less than 3 nM for wild type and Tyr646 mutated EZH2. It displays 15-fold selectivity for EZH2 over EZH1 and is without effect against an...

    $1,239 - $4,018
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  • Cercosporamide

    Biovision | Cercosporamide | 9662

    Cercosporamide is a potent inhibitor of MAP-kinase interacting kinases (Mnk1 and Mnk2), and JAK3 (IC₅₀ values are 115, 11, and 31 nM for Mnk1, Mnk2 and JAK3, respectively). Also inhibits Pkc1. Blocks...

    $1,008 - $3,129
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  • TG6-10-1

    Biovision | TG6-10-1 | 9646

    TG6-10-1 is a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2. Displays low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4,...

    $1,008 - $3,129
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  • SH-4-54

    Biovision | SH-4-54 | B1637

    SH-4-54 is a most potent, small molecule, non-phosphorylated STAT3 inhibitor, strongly binds to STAT3 protein (KD = 300 nM), is selective for STAT3 over STAT1.SH-4-54 is a most potent, small...

    $809 - $2,125
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  • SR9243

    Biovision | SR9243 | 9642

    SR9243 is a potent , cell-permeable and selective LXR inverse agonist. SR9243 kills cancer cells by inhibiting lipid production and the Warburg effect. It induces cell death in multiple types of...

    $837 - $2,440
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  • SBI-0206965

    Biovision | SBI-0206965 | 9580

    SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor. It inhibits ULK1 kinase with IC₅₀ of 108 nM and the highly related kinase ULK2 with IC₅₀ of 711 nM. SBI-0206965...

    $1,008 - $3,129
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  • ARV-825

    Biovision | ARV-825 | B2019

    ARV-825 is a BRD4 inhibitor. It is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged...

    $777 - $2,209
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  • JH-II-127

    Biovision | JH-II-127 | 9632

    JH-II-127 is a highly potent, selective, and cell-permeable LRRK2 inhibitor, with IC₅₀ of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. JH-II-127 substantially inhibits...

    $1,008 - $3,129
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  • Pexmetinib

    Biovision | Pexmetinib | B1711

    Pexmetinib (ARRY-614) is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.Pexmetinib (ARRY-614)...

    $1,120 - $3,584
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  • Fevipiprant

    Biovision | Fevipiprant | B1588

    Fevipiprant is a prostaglandin D2 (PGD2) receptor antagonist with a Kd value of 1.14 nM for CRTH2/DP2. It has been shown to inhibit PGD2-stimulated human eosinophil shape change in whole blood assays...

    $1,008 - $3,129
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  • Remodelin

    Biovision | Remodelin | 9411

    Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10 that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization...

    $809 - $2,328
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  • BRD4770

    Biovision | BRD4770 | 9525

    BRD4770 is a selective inhibitor of the histone methyltransferase G9a (also named euchromatin histone methyltransferase 2 (EHMT2). BRD4770 blocks lysine residue 9 methylation of histone H3 without...

    $1,008 - $3,129
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