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Biovision

  • BV6

    Biovision | BV6 | B1332

    BV6 is a selective inhibitor of IAP proteinsBV6 is a selective inhibitor of IAP proteinsBiovision | B1332 | BV6 DataSheetAlternate Name/Synonyms:...

    $1,292 - $3,875
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  • Nexturastat A

    Biovision | Nexturastat A | 2098

    Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC₅₀ = 5.02 ± 0.60 nM). Displays 600-, 1380-, 1330-, 1870-, -2330,...

    $1,036
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  • TAPI-1

    Biovision | TAPI-1 | 2068

    Inhibitor of TNF-α processing (IC₅₀ = 100 nM), similar to TAPI-0 (Cat. No. 2067-1), but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- α...

    $2,125
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  • CNX-1351

    Biovision | CNX-1351 | B1673

    CNX1351 is a potent and selective inhibitor of PI3Kα with IC50 value of 6.8 nMCNX1351 is a potent and selective inhibitor of PI3Kα with IC50 value of 6.8 nMBiovision | B1673 | CNX-1351...

    $865 - $2,587
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  • Brefeldin A

    Biovision | Brefeldin A | 1560

    Brefeldin A has been shown to induce apoptosis in human tumor cells through caspase activation. It has also been shown to block translocation of proteins from the endoplasmic reticulum to the Golgi...

    $851 - $2,499
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  • Birinapant

    Biovision | Birinapant | 2597

    Birinapant is a SMAC (synthetic small molecule and peptidomimetic of second mitochondrial-derived activator of caspases) mimetic and IAP (Inhibitor of Apoptosis Protein) antagonist with potential...

    $718 - $1,985
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  • PFI-1

    Biovision | PFI-1 | 2203

    PFI-1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. In an AlphaScreen assay it has been shown to inhibit BRD2 bromodomain 2 and BRD4 bromodomain 1 with IC₅₀...

    $637 - $1,463
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  • VS-5584

    Biovision | VS-5584 | 9603

    VS-5584 is a potent and selective PI3K/mTOR kinase inhibitor. It inhibits mTOR (IC₅₀ = 37 nM) and PI3K (IC₅₀s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively) without relevant...

    $777 - $2,209
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  • Sapacitabine

    Biovision | Sapacitabine | B2002

    Sapacitabine is an orally bioavailable nucleoside analog prodrug that is potentially useful for treatment of hematologic malignancies and solid tumors. The active metabolite of sapacitabine, CNDAC...

    $1,582 - $5,422
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  • Briciclib

    Biovision | Briciclib | B1140

    Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. Cyclin D, a member of the cyclin family of cell cycle regulators, plays a key role in cell cycle division and is...

    $1,239 - $3,875
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  • Nimorazole

    Biovision | Nimorazole | 9521

    Nimorazole is a 5-nitroimidazole derivative that displays antimicrobial activity. Used in the treatment of intestinal protozoal infections. Also acts as a hypoxic radiosensitizer.Nimorazole is a...

    $718 - $1,411
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  • Kartogenin

    Biovision | Kartogenin | 2066

    Cell-permeable. Kartogenin promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes (EC₅₀ = 100 nM). Displays chondroprotective effects in vitro and is...

    $809 - $2,352
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  • Ethynylcytidine

    Biovision | Ethynylcytidine | B1266

    Ethynylcytidine is a synthetic cytidine nucleoside containing a covalently bound ethynyl group with potential antineoplastic and radiosensitizing activities. Ethynylcytidine is metabolized in tumor...

    $1,061 - $3,357
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  • Cilengitide

    Biovision | Cilengitide | B2365

    Cilengitide is a cyclo-(Arg-Gly-Asp-D-Phe-Val) (cRGDfV) peptide that acts as an integrin αVβ3 receptor antagonist. It inhibits adhesion and induces apoptosis of U87MG and U373MG malignant glioma (MG)...

    $949 - $2,898
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  • BMS-303141

    Biovision | BMS-303141 | 2821

    BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL) (IC₅₀ = 0.13 µM for human recombinant ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC₅₀ of 8 μM, and lowers plasma...

    $1,120 - $3,644
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  • Arglabin

    Biovision | Arglabin | 9691

    Arglabin is a potent anti-inflammatory and anticancer agent. It also acts as a Farnesyltransferase inhibitor and antiatherogenic compound. Prevents the accumulation of lipid containing plaques in...

    $1,351 - $4,501
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  • ACTB-1003

    Biovision | ACTB-1003 | B2016

    ACTB-1003 is a potent kinase inhibitor with IC₅₀s of 6, 2 and 4 nM for FGFR1, VEGFR2 and Tie-2, respectively. Displays anticancer activities.ACTB-1003 is a potent kinase inhibitor with IC₅₀s of 6, 2...

    $1,292 - $4,277
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  • Citarinostat

    Biovision | Citarinostat | B1560

    Citarinostat (ACY-241), is a potent, selective and orally available histone deacetylase 6 (HDAC6) inhibitor with IC₅₀ values of 4 nM and 76 nM for HDAC6 and HDAC3, respectively. Displays...

    $1,061 - $3,357
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  • SM-164

    Biovision | SM-164 | B1816

    SM-164 is a potent cell-permeable and bivalent Smac mimetic which binds to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM,...

    $889 - $1,894
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  • CTx-0294885

    Biovision | CTx-0294885 | 9435

    CTx-0294885 is a broad-spectrum kinase inhibitor. CTx-0294885 displays inhibitory activity against a broad range of kinases in vitro. CTx-0294885 could be a potentially powerful new tool for analysis...

    $1,008 - $2,958
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  • P7C3-A20

    Biovision | P7C3-A20 | 2850

    P7C3-A20 is a derivative of P7C3 (Cat. No. 2849), and is a proneurogenic, neuroprotective agent. P7C3-A20 displays increased activity and an improved toxicity profile compared to P7C3...

    $1,008 - $2,958
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  • P7C3

    Biovision | P7C3 | 2849

    P7C3 is an aminopropyl carbazole derivative that acts as a proneurogenic, neuroprotective compound. Protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and...

    $1,061 - $3,129
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  • Uprosertib

    Biovision | Uprosertib | B1760

    Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.Uprosertib,...

    $1,120 - $3,584
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  • DBeQ

    Biovision | DBeQ | 1858

    Cell- permeable. A potent, selective, reversible, and ATP-competitive p97 inhibitor. DBeQ blocks both ubiquitin-dependent and autophagic protein clearance pathways and rapidly promotes executioner...

    $837 - $2,384
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  • X-GAL

    Biovision | X-GAL | 2671

    X-GAL is a useful chromogenic substrate for β-galactosidase that produces a rich blue color that can easily be detected visually over background. X-GAL is used to indicate whether a cell expresses...

    $1,120 - $3,584
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  • Luminol

    Biovision | Luminol | B1807

    Luminol is a useful probe that displays chemiluminescence upon oxidation. Horseradish peroxidase (HRP), combined with hydrogen peroxide as an activator, causes luminescent peroxidation of luminol...

    $665 - $1,582
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  • DTT

    Biovision | DTT | 1201

    An excellent reagent for maintaining SH groups in reduced state. DTT quantitatively reduces disulfides. It is effective in sample buffers for reducing protein disulfide bonds prior to SDSPAGE.DTT is...

    $809
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  • DTE

    Biovision | DTE | B2410

    A useful reagent for maintaining sulfhydryl groups in the reduced stateDTE is a useful reagent for maintaining sulfhydryl groups in the reduced stateBiovision | B2410 | DTE DataSheetAlternate...

    $777 - $3,987
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  • Y-320

    Biovision | Y-320 | B1164

    Y-320 is an immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.Y-320 is an immunomodulator. Y-320 inhibits IL-17 production by CD4 T...

    $1,008 - $3,129
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  • DMOG

    Biovision | DMOG | 2216

    A cell-permeable prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic...

    $637 - $1,582
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  • PTC-209

    Biovision | PTC-209 | B1055

    PTC-209 is a potent, cell-permeable, BMI-1 inhibitor (IC₅₀ = 0.5 µM) with potential anticancer activity. PTC-209 lowers the self-renewal properties of colorectal cancer-initiating cells (CICs)...

    $1,061 - $3,129
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  • TCS JNK 5a

    Biovision | TCS JNK 5a | B1688

    TCS JNK 5a (JNK Inhibitor IX) is a selective inhibitor of JNK2 and JNK3; displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2, PLK-1 and Src (pIC50 < 5.0)...

    $665 - $2,037
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  • Inauhzin

    Biovision | Inauhzin | 9555

    Inauhzin is a potent SIRT inhibitor that effectively reactivates p53 by inhibiting SIRT1 activity. Inauhzin inhibits cell proliferation, induces senescence, and p53-dependent apoptosis of human...

    $1,411 - $4,851
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  • HS-173

    Biovision | HS-173 | B1627

    HS-173 is a novel PI3K inhibitor, that is used for cancer treatment. HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells.HS-173 is a novel PI3K...

    $809 - $2,328
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  • FLI-06

    Biovision | FLI-06 | 2603

    A potent Notch signaling (EC₅₀ = 2.3 µM) as well as the early secretory pathway inhibitor. FLI-06 leads to a disruption of the Golgi by a mechanism different from Brefeldin A (Cat. No. 1560) or other...

    $1,008 - $3,070
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  • Atglistatin

    Biovision | Atglistatin | B1864

    Atglistatin is a potent, and selective inhibitor of adipose triglyceride lipase (ATGL) the rate limiting enzyme involved in fatty acid mobilization and prevention of lipolysis. It does not inhibit...

    $1,120 - $3,584
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  • AdipoRon

    Biovision | AdipoRon | 2565

    A potent and selective adiponectin receptor agonist (Kd = 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively). Displays similar effects to adiponectin in muscle and liver such as activation of...

    $1,008 - $3,129
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  • CPI-203

    Biovision | CPI-203 | 9404

    CPI-203 is an analog of (+)-JQ1 (Cat. No. 2070). Acts as a BET bromodomain inhibitor. It is comparable or superior to (+)-JQ1 in inhibiting BRD4 binding and action in vitro or in cells.CPI-203...

    $718 - $1,985
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  • SF1670

    Biovision | SF1670 | 2774

    SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor (IC₅₀ = 2 µM). It specifically binds to the active site of PTEN. At nanomolar concentrations it increases cellular...

    $837 - $2,440
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  • ID-8

    Biovision | ID-8 | 2562

    ID-8 is a cell culture supplement that can sustain self-renewal and pluripotency of mouse embryonic stem cells in vitro. At 10 μM it stimulates proliferation in serum-free media at a steady rate for...

    $1,008 - $3,129
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  • SAR-260301

    Biovision | SAR-260301 | B1263

    SAR260301 is a potent and selective Class I phosphatidylinositol-3-kinase-β (PI3K-β) specific inhibitor with an IC₅₀ of 52 nM for this isoform. SAR260301 displays improved physicochemical and in...

    $1,120 - $3,584
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  • BAY 87-2243

    Biovision | BAY 87-2243 | B1878

    BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation. It inhibits HIF-1α and HIF-2α protein accumulation under hypoxic conditions in non-small cell lung cancer...

    $1,411 - $4,732
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  • NSC 405020

    Biovision | NSC 405020 | 2682

    NSC-405020 is a membrane type-I matrix metalloproteinase (MT1-MMP) inhibitor that specifically targets the hemopexin (PEX) domain rather than the catalytic domain of MT1-MMP (IC₅₀ >100 μmol/L). It...

    $718 - $1,985
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  • SGC-CBP30

    Biovision | SGC-CBP30 | 9554

    SGC-CBP30 is a potent and selective CREBBP/EP300 bromodomain inhibitor with IC values of 21-69 and 38 nM for CREBBP and EP300 bromodomains, respectively. SGC-CBP30 has little activity against other...

    $1,411 - $4,851
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  • Bromosporine

    Biovision | Bromosporine | 2652

    Bromosporine is a broad spectrum bromodomain inhibitor (IC₅₀s = 0.41 µM, 0.29 µM, 0.122 µM and 0.017 µM for BRD2, BRD4, BRD9 and CECR2, respectively). At 1 µM, Bromosporine accelerates FRAP recovery...

    $718 - $1,985
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  • UNC2881

    Biovision | UNC2881 | 2837

    UNC2881 is a potent Mer kinase inhibitor. It inhibits steady-state Mer kinase phosphorylation with an IC₅₀ value of 22 nM. Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation...

    $837 - $2,440
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  • HG-9-91-01

    Biovision | HG-9-91-01 | B1849

    HG-9-91-01 is a potent, selective, ATP-competitive, pan-SIK (salt-inducible kinases) inhibitor with IC₅₀ values of 0.92 nM, 6.6n M and 9.6 nM for SIK1, SIK2, SIK3, respectively.HG-9-91-01 is a...

    $949 - $2,898
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  • PF-4708671

    Biovision | PF-4708671 | 9460

    PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with a Ki of 20 nM and IC₅₀ of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in...

    $1,239 - $4,018
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  • TAK-632

    Biovision | TAK-632 | 2473

    A selective pan-RAF inhibitor with IC₅₀ Values: 2.4 nM (BRAF V600E); 1.4 nM (C-RAF); 160 nM (VEGFR). TAK-632 displays significant cellular activity against mutated BRAF or mutated NRAS cancer cell...

    $1,008 - $3,070
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  • Erastin

    Biovision | Erastin | 2231

    Erastin is a selective antitumor agent that displays greater lethality in human tumour cells harbouring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to mitochondrial volatage-dependent...

    $1,061 - $28,420
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  • Valdecoxib

    Biovision | Valdecoxib | B1991

    Valdecoxib is a non-steroidal anti-inflammatory drug (NSAID), that acts as a potent and selective inhibitor of cyclooxygenase-2 (COX-2) (IC₅₀ = 5 nM).Valdecoxib is a non-steroidal anti-inflammatory...

    $1,008 - $3,014
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  • Necrostatin-1

    Biovision | Necrostatin-1 | 1864

    Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in...

    $718 - $1,694
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