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Biovision

  • RKI-1447

    Biovision | RKI-1447 | 2472

    A highly potent inhibitor of Rho-associated kinases ROCK1 and ROCK2 (IC₅₀ values: 14.5 nM for ROCK1 and 6.2 nM for ROCK2). RKI-1447 suppresses ROCK-dependent signaling, cell morphology,...

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  • Ellipticine

    Biovision | Ellipticine | 9579

    Ellipticine is a naturally occurring plant alkaloid that acts as a DNA intercalating agent and DNA topoisomerase II inhibitor. Ellipticine is also shown to block p53 protein phosphorylation...

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  • GNF-5

    Biovision | GNF-5 | B1329

    GNF-5 is a selective non-ATP competitive inhibitor of Bcr-AblGNF-5 is a selective non-ATP competitive inhibitor of Bcr-AblBiovision | B1329 | GNF-5 DataSheetAlternate Name/Synonyms:...

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  • DB07268

    Biovision | DB07268 | B1134

    DB07268 is a potent and selective JNK1 inhibitor with (IC₅₀ = 9 nM). DB07268 displays some degree of selectivity over quite a few kinases with the exceptions of CHK1, CK2, and PLK. Although DB07268...

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  • AGI-6780

    Biovision | AGI-6780 | 9624

    AGI-6780 is a potent, selective inhibitor of mutant Isocitrate dehydrogenase 2 (IDH2) (IC₅₀ = 23 nM). It binds allosterically at the dimer interface of mutant IDH2-R140Q, inhibiting...

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  • Poziotinib

    Biovision | Poziotinib | 9519

    Poziotinib is an irreversible Pan-HER inhibitor with IC₅₀s of 3 nM, 5 nM and 23 nM for HER1, HER2, and HER4 respectively. Displays antineoplastic activity.Poziotinib is an irreversible Pan-HER...

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  • NSC 23766

    Biovision | NSC 23766 | 1941

    A cell-permeable, reversible, and selective Rac1 inhibitor; inhibiting Rac1 activation by the Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam 1 (IC₅₀ = 50 μM) without affecting...

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  • FH535

    Biovision | FH535 | 2657

    FH535 is a potent, reversible dual inhibitor of Wnt/β-catenin and a PPARγ and PPARδ signaling. FH535 antagonizes both PPARg and PPARδ ligand-dependent activation and shows structural similarity to...

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  • Kobe2602

    Biovision | Kobe2602 | B1710

    Kobe2602 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; exhibits potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki...

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  • Kobe0065

    Biovision | Kobe0065 | B1714

    Kobe0065 is a small-molecule inhibitor of Ras with Ki value of 46 μM for the binding of H-Ras.GTP to c-Raf-1Kobe0065 is a small-molecule inhibitor of Ras with Ki value of 46 μM for the binding of...

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  • NMS-873

    Biovision | NMS-873 | 9600

    NMS-873 is a potent, selective, allosteric inhibitor of the ATPase VCP/p97 (IC₅₀ = 30 nM). NMS-873 activates the unfolded protein response, interferes with autophagy and induces cancer cell death...

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  • NS6180

    Biovision | NS6180 | B1640

    NS6180 is a novel potent and selective KCa3.1 channel inhibitor (IC50= 9nM) prevents T-cell activation and inflammation.NS6180 is a novel potent and selective KCa3.1 channel inhibitor (IC50= 9nM)...

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  • QNZ46

    Biovision | QNZ46 | B2007

    QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC₅₀ values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively)QNZ46 is a...

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  • Leukadherin-1

    Biovision | Leukadherin-1 | 2059

    A novel small molecule agonist of integrin CD11b/CD18 (also known as Mac-1). LA1 increases the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse...

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  • PluriSIn 1

    Biovision | PluriSIn 1 | 2471

    A selective inhibitor of steroyl-CoA desaturase 1 (SCD1), the key enzyme in oleic acid biosynthesis. PluriSIn 1, induces ER stress, protein synthesis attenuation, and apoptosis in hPSCs (human...

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  • TUG-770

    Biovision | TUG-770 | B1166

    TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC₅₀ of 6 nM for hFFA1.The FFA1 increases glucose stimulated insulin secretion from pancreatic β-cells and efficiently...

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  • TTNPB

    Biovision | TTNPB | 2776

    TTNPB is a highly potent retinoic acid receptor (RAR) agonist (EC₅₀ = 21 nM, 4.0 nM, and 2.4 nM for RARα, RARβ, and RARγ, respectively). Enhances reprogramming efficiency in chemically induced...

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  • GZD824

    Biovision | GZD824 | 2795

    GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC₅₀ of 0.34 nM and 0.68 nM, respectively.GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for...

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  • XMD17-109

    Biovision | XMD17-109 | B1685

    XMD17-109 is a novel, specific ERK-5 inhibitor, which inhibits the ERK5-mediated AP1 transcriptional activity at 30 μM, and has an EC50 of 4.2 μM.XMD17-109 is a novel, specific ERK-5 inhibitor, which...

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  • IPA-3

    Biovision | IPA-3 | 2647

    IPA-3 is a cell-permeable allosteric inhibitor of PAK1 (tha p21-activated kinase 1) that is non-competitive with respect to ATP binding (IC₅₀ = 2.5 µM). It does not, however, inhibit the activity of...

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  • GW1929

    Biovision | GW1929 | 2057

    A potent (1000-fold) peroxisome proliferator-activated receptor (PPAR)γ agonist. Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo.GW1929 is a potent...

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  • Alvelestat

    Biovision | Alvelestat | B1653

    Alvelestat (AZD9668) is a novel, oral inhibitor of neutrophil elastase (NE) with the pIC50 of 7.9 for Human NE.Alvelestat (AZD9668) is a novel, oral inhibitor of neutrophil elastase (NE) with the...

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  • SGC0946

    Biovision | SGC0946 | 2448

    A potent and selective DOT1L inhibitor (IC₅₀ = 0. 3 nM in a radioactive enzyme assay); >100-fold selective for other histone methyltransferases (HMTs). SGC0946 also potently reduces H3K79...

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  • UNC1999

    Biovision | UNC1999 | 2449

    A potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC₅₀ = 2 nM). UNC1999 is >1000-fold selective for other HMTs except EZH1 (22-fold selectivity). It inhibits H3K27 methylation...

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  • LY 303511

    Biovision | LY 303511 | B1734

    LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K.LY303511, an inactive analogue of LY294002, is a mTOR inhibitor that did not inhibit PI3-K.Biovision | B1734...

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  • JNK-IN-7

    Biovision | JNK-IN-7 | B1695

    JNK-IN-7 is a selective JNK inhibitor with IC50 values of 1.54 nM, 1.99 nM, 0.75 nM to JNK1, JNK2, JNK3, respectively. It also inhibits phosphorylation of c-Jun, which is a direct substrate of JNK...

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  • GDC-0623

    Biovision | GDC-0623 | B1690

    GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).GDC-0623...

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  • AZD-3463

    Biovision | AZD-3463 | 2371

    AZD-3463 is a potent ALK (Anaplastic Lymphoma Kinase)/IGFR1 dual inhibitor that displays ability to overcome acquired resistance to Crizotinib (Cat. No.1934).AZD-3463 is a potent ALK (Anaplastic...

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  • Encorafenib

    Biovision | Encorafenib | B2103

    Encorafenib (LGX818) is a potent mutated BRafV600E inhibitor (IC₅₀ = 0.3 nM) with potential antineoplastic activity. Displays little activity against wild-type B-Raf or a panel of 100 other kinases...

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  • Ledipasvir

    Biovision | Ledipasvir | B2338

    Ledipasvir is a potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV. Upon oral administration and after...

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  • SSR128129E

    Biovision | SSR128129E | B1165

    SSR128129E (SSR) is a potent small molecule, allosteric inhibitor of FGFR signaling. SSR binds to the extracellular part of the receptor and it does not compete with FGF for binding to FGFR but...

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  • EI1

    Biovision | EI1 | B2270

    EI1 is a potent EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC₅₀s = 15 and 13 nM, respectively). It displays 90-fold selectivity for EZH2 over EZH1 and >10,000-fold...

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  • AZ20

    Biovision | AZ20 | B1724

    AZ20 is a potent and selective inhibitor of ATR kinase with IC50 value of 5 nM.AZ20 is a potent and selective inhibitor of ATR kinase with IC50 value of 5 nM.Biovision | B1724 | AZ20...

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  • FRAX597

    Biovision | FRAX597 | B1890

    FRAX597 is a potent group I PAK (p21-activated kinase) inhibitor (IC₅₀ values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). Displays significant inhibition of YES1, RET, CSF1R and TEK at 100...

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  • JC-1

    Biovision | JC-1 | 1130

    JC-1 is a mitochondrial dye that stains mitochondria in living cells in a membrane potential-dependent fashion. JC-1 monomer is in equilibrium with so called J-aggregates, which are favored at higher...

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  • S0859

    Biovision | S0859 | 9425

    S0859 is a selective high-affinity generic inhibitor of the Na⁺/HCO3- sodium bicarbonate co-transporter (NBC). S0859 does not inhibit Na⁺-H⁺ exchange (NHE). S0859 could be potentially important for...

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  • kb NB 142-70

    Biovision | kb NB 142-70 | 9566

    kb NB 142-70 is a selective protein kinase D (PKD) inhibitor with IC₅₀ values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively. More potent analog of CID-755673 (Cat.No. 2660) with 7-fold...

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  • ETP-46464

    Biovision | ETP-46464 | 2457

    A potent ATR (ATM and Rad3-related) inhibitor (IC₅₀ = 25 nM). It also inhibits the activity of PI3Kα, mTOR and DNA-PKC with IC₅₀'s of 170, 0.6 and 36 nM, respectively. ETP-46464 inhibits the restart...

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  • CGK733

    Biovision | CGK733 | B1725

    CGK 733 is a potent and selective inhibitor of ATM/ATR with an IC50 value of ~200 nM.CGK 733 is a potent and selective inhibitor of ATM/ATR with an IC50 value of ~200 nM.Biovision | B1725 | CGK733...

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  • LCL161

    Biovision | LCL161 | B1601

    A SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP)A SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP)Biovision | B1601 | LCL161...

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  • OTSSP167

    Biovision | OTSSP167 | B1065

    OTSSP167 is an inhibitor (IC₅₀ = 0.41 nM) of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. OTSSP167 binds to MELK, which prevents both MELK phosphorylation...

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  • VGX-1027

    Biovision | VGX-1027 | B1632

    VGX-1027(GIT27) is an orally active immunomodulatory agent and a isoxazole compound that exhibits various immunomodulatory properties; reduce the secretion of IL-1beta, TNF-alpha and IL-10 from...

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  • PF-670462

    Biovision | PF-670462 | B2271

    PF-670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC₅₀ values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other kinases. Inhibits PER...

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  • Scriptaid

    Biovision | Scriptaid | 1605

    A relatively non-toxic Inhibitor of histone deacetylase (HDAC). Facilitates transcriptional activation (TGF-β/Smad4) in both stable and transient receptor assays in a concentration-dependent manner...

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  • Salubrinal

    Biovision | Salubrinal | 1980

    Cell-permeable. A selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Also protects cells from endoplasmic...

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  • DY131

    Biovision | DY131 | 2775

    DY131 is a selective agonist at estrogen-related receptors ERRβ and ERRγ. It displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μMDY131 is a selective agonist at...

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  • D-64131

    Biovision | D-64131 | B1066

    D-64131 is a potent tubulin polymerization inhibitor. Cytotoxic and inhibits tumor cell proliferation in vitro (IC₅₀ = 74 nM). Antimitotic agent. Induces G2/M cell cycle arrest.D-64131 is a potent...

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  • VU 0364439

    Biovision | VU 0364439 | 2815

    VU-0364439 is a potent positive allosteric modulator (PAM) of mGluR-4 (metabotropic glutamate receptor) (EC₅₀ = 19.8 nM in vitro for human mGluR-4).VU-0364439 is a potent positive allosteric...

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  • UK-5099

    Biovision | UK-5099 | B1952

    UK-5099 is a potent and specific inhibitor of MPC (mitochondrial pyruvate carrier) activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria with an IC₅₀ value of...

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