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Biovision

  • Purmorphamine

    Biovision | Purmorphamine | 1672

    A 2,6,9-trisubstituted purine that promotes the differentiation of both human and murine mesenchymal progenitor cells into osteoblasts. It directly binds to and activates 7-transmembrane Smo receptor...

    $1,208
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  • Balicatib

    Biovision | Balicatib | 2596

    Cell-permeable. Balicatib is a potent human cathepsin K inhibitor in vitro (IC₅₀ = 1.4 nM) with a high selectivity against human cathepsins B, L, and S (> 4,800-fold, > 500-fold and > 65,000-fold,...

    $837 - $2,296
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  • Apoptozole

    Biovision | Apoptozole | B2412

    Apoptozole is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively. Apoptozole dose-dependently induces apoptosis in cancer cells (IC₅₀ = 5-7 µM). It...

    $1,120 - $3,584
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  • StemRegenin 1

    Biovision | StemRegenin 1 | 1967

    A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold...

    $809 - $1,925
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  • Dalcetrapib

    Biovision | Dalcetrapib | 2419

    Dalcetrapib is a potent CETP modulator. It is a thioester pro-drug that is rapidly hydrolyzed to generate a pharmacologically active thiol. Dalcetrapib modulates cholesteryl ester transfer protein...

    $718 - $1,866
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  • Bardoxolone

    Biovision | Bardoxolone | B1170

    Bardoxolone is a synthetic oleanane triterpenoid that inhibits cellular iNOS production when stimulated by IFNg, TNF-α and IL-1. It is Reata’s investigational lead molecule for CKD (chronic kidney...

    $1,008 - $3,129
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  • Vidofludimus

    Biovision | Vidofludimus | B1633

    Vidofludimus is a novel immunosuppressive drug that inhibits DHODH; inhibits IL-17 secretion in vitro independently of effects on lymphocyte proliferation.Vidofludimus is a novel immunosuppressive...

    $865 - $2,587
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  • Eliglustat

    Biovision | Eliglustat | B1217

    Eliglustat is a potent and specific inhibitor of glucosylceramide synthase. Eliglustat is a new promising substrate reduction therapy (SRT) for Gaucher disease (GD). Eliglustat works by inhibiting...

    $1,239 - $4,018
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  • Bedaquiline

    Biovision | Bedaquiline | 9598

    Bedaquiline is an anti-tuberculosis drug. Bedaquiline's unique and specific anti-mycobacterial activity derives from inhibition of the proton pump of mycobacterial ATP synthase, which is a critical...

    $1,411 - $4,449
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  • Tideglusib

    Biovision | Tideglusib | 9601

    Tideglusib is a potent, irreversible, non ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC₅₀ = 60 nM).Tideglusib is a potent, irreversible, non ATP-competitive glycogen synthase...

    $777 - $2,209
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  • Delafloxacin

    Biovision | Delafloxacin | B1950

    Delafloxacin (ABT-492) is a fluoroquinolone antibiotic that displays high potency against a wide range of bacteria in vitro, including levofloxacin-resistant strains of S. pneumoniae and...

    $837 - $2,440
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  • Teneligliptin

    Biovision | Teneligliptin | B1932

    Teneligliptin is a potent DPP-4 (dipeptidylpeptidase-4) inhibitor, that competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC₅₀s of approximately 1 nM. Useful...

    $1,008 - $3,129
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  • Salirasib

    Biovision | Salirasib | B2097

    Salirasib is a potent Inhibitor of active Ras proteins. It displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also...

    $949 - $2,898
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  • Elvitegravir

    Biovision | Elvitegravir | 9465

    Elvitegravir is a novel HIV-1 integrase inhibitor that blocks strand transfer by the viral enzyme. It displays an IC₅₀ of 7.2 nM in the strand transfer assay, and shows an EC₅₀ of 0.9 nM in an acute...

    $949 - $2,898
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  • VE-821

    Biovision | VE-821 | B1723

    VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.Biovision |...

    $1,061 - $3,357
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  • Reversine

    Biovision | Reversine | 1851

    A cell-permeable, potent, and selective human A3 adenosine receptor antagonist (Ki = 0.66 μM) and an aurora kinase inhibitor (IC₅₀'s of 30-550 nM for blast colony formation assay). Induces...

    $578 - $1,292
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  • Refametinib

    Biovision | Refametinib | B1889

    Refametinib (BAY 86-9766; previously RDEA119) is a highly selective and potent orally available inhibitor of MEK 1 and MEK 2. It displays potent in vitro and in vivo antitumor activity in multiple...

    $1,008 - $3,129
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  • Firocoxib

    Biovision | Firocoxib | B1986

    Firocoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent and selective cyclooxygenase (COX)-2 inhibitor with an IC₅₀ of 0.13 uM. Displays 58-fold selectivity for COX-2 vs...

    $1,411 - $4,589
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  • Lomitapide

    Biovision | Lomitapide | 2876

    Lomitapide is a small molecule that lowers total cholesterol levels by inhibiting microsomal triglyceride transfer protein (MTTP) and preventing the assembly of apoB-containing lipoproteins and VLDL...

    $949 - $2,898
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  • Fluvastatin

    Biovision | Fluvastatin | B2366

    Fluvastatin is a potent and selective HMG-CoA reductase inhibitor. It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits increases in serum...

    $665 - $1,754
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  • Sulfasalazine

    Biovision | Sulfasalazine | B2331

    An anti-inflammatory agent and GST inhibitor. Sulfasalazine inhibits TNF-α and LPS-induced NF-κB activation in SW620 colon cancer cells. It also inhibits degradation of IκBα and prevents nuclear...

    $718 - $1,411
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  • DHEA

    Biovision | DHEA | 2172

    DHEA is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. It is a negative modulator of GABAA receptors. DHEA inhibits the activity of G6PD (glucose 6-phosphate...

    $606 - $1,351
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  • Retinoic acid

    Biovision | Retinoic acid | 2218

    Retinoic acid is a metabolite of vitamin A that acts as a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RAR and RXR heterodimerize and act as ligand-dependent...

    $690 - $1,813
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  • Clioquinol

    Biovision | Clioquinol | 2454

    An antiparasitic agent that forms stable complexes with copper and used for treatment of Alzheimer’s disease. Displays anticancer properties by inhibition of proteasome activity. It targets tumor...

    $665 - $1,180
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  • Kaempferol

    Biovision | Kaempferol | 2523

    A naturally occurring polyphenol antioxidant that displays a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective,...

    $777 - $2,209
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  • Lopinavir

    Biovision | Lopinavir | 2241

    A protease inhibitor with high specificity for HIV-1 protease. Inhibition of HIV-1 protease (responsible for protein cleavage), results in selectively inhibiting the cleavage of HIV gag and gag-pol...

    $606 - $1,292
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  • PF-03814735

    Biovision | PF-03814735 | B1257

    PF-03814735 is an ATP-competitive inhibitor of Aurora kinases A and B with IC₅₀values of 0.8 and 0.5 nM respectively. It has shown to block cytokinesis, inhibit cellular proliferation in many tumor...

    $1,292 - $4,277
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  • TBPB

    Biovision | TBPB | B1041

    TBPB is a highly selective allosteric Muscarinic M1 agonist (EC₅₀ = 289 nM). TBPB increases non-amyloidogenic APP processing and produces antipsychotic-like effects in rodent models predictive of...

    $1,061 - $3,357
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  • Aripiprazole

    Biovision | Aripiprazole | B1186

    Aripiprazole is a high affinity dopamine D2 and 5-HT1A receptor partial agonist (Ki values are ~1.64 and 5.59 nM respectively). Also 5-HT2A antagonist (Ki = 8.7 nM). Aripiprazole is a clinically...

    $665 - $1,411
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  • YK-4-279

    Biovision | YK-4-279 | 2846

    YK-4-279 is an Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. At 10 µM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s...

    $837 - $2,440
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  • JNJ-31020028

    Biovision | JNJ-31020028 | 9648

    JNJ-31020028 is a selective brain -penetrant small molecule antagonist of the neuropeptide Y2 (NPY2) receptor.JNJ-31020028 is a selective brain -penetrant small molecule antagonist of the...

    $1,008 - $3,129
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  • XMD8-92

    Biovision | XMD8-92 | B1684

    XMD8-92 is a highly selective ERK5/BMK1 inhibitor with dissociation constant (Kd) value of 80 nM.XMD8-92 is a highly selective ERK5/BMK1 inhibitor with dissociation constant (Kd) value of 80 nM...

    $949 - $2,811
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  • ICG-001

    Biovision | ICG-001 | 2275

    A specific inhibitor of Wnt/β-catenin signaling pathway. It down-regulates beta-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein (CBP). ICG-001...

    $1,008 - $3,070
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  • VU0361737

    Biovision | VU0361737 | 9418

    VU 0361737 is a selective, brain-permeable, positive allosteric modulator at mGlu4 receptors (EC₅₀ values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3,...

    $949 - $2,898
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  • Fosaprepitant

    Biovision | Fosaprepitant | 9529

    Fosaprepitant is a prodrug of Aprepitant (Cat. No. 9531) that acts as a selective, high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. After biologically activated to...

    $949 - $2,898
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  • RAD140

    Biovision | RAD140 | B1211

    RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM) that demonstrates excellent affinity for the androgen receptor (Ki = 7 nM). It displays potent...

    $1,008 - $3,014
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  • Elagolix sodium

    Biovision | Elagolix sodium | B2112

    Elagolix sodium is a human GnRH (Gonadotropin-Releasing Hormone) receptor antagonist with an IC₅₀ and Ki of 0.25 and 3.7 nM, respectively. Elagolix alters the level of pituitary GnRH suppression and,...

    $1,008 - $3,129
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  • AC-55541

    Biovision | AC-55541 | 9412

    AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC₅₀ = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and...

    $777 - $2,209
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  • Vildagliptin

    Biovision | Vildagliptin | 2188

    An antidiabetic agent. A potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that breaks down Glucagon-like peptide 1 (GLP-1). By delaying the degradation of GLP-1, vildagliptin extends...

    $1,239 - $3,332
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  • Entacapone

    Biovision | Entacapone | B1190

    Entacapone is a potent catechol O-methyl transferase (COMT) inhibitor with IC₅₀ values of 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT, respectively...

    $718 - $1,925
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  • Anastrozole

    Biovision | Anastrozole | B2177

    Anastrozole is a potent aromatase inhibitor that has been shown to effectively eliminate the conversion of androgens to estrogens in peripheral tissues. It inhibits human placental aromatase in vitro...

    $665 - $1,722
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  • Milrinone

    Biovision | Milrinone | 2163

    Cell-permeable. A potent, cAMP-specific phosphodiesterase (PDEIII ) inhibitor (IC₅₀ = 0.45 and 1.0 µM for PDEIIIA and PDEIIIB, respectively). It inhibits other PDE isoforms at much higher...

    $980 - $2,842
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  • Letrozole

    Biovision | Letrozole | B2042

    Letrozole is a third-generation nonsteroidal cell-permeable aromatase inhibitor (IC₅₀ = 2 nM). It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of...

    $777 - $2,156
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  • Macitentan

    Biovision | Macitentan | B1856

    Macitentan is an orally active endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH).Macitentan is an orally active endothelin receptor antagonist...

    $777 - $2,209
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  • VX-11e

    Biovision | VX-11e | B1681

    VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase); antitumor agent.VX-11e is a potent, selective, and orally bioavailable inhibitor of...

    $949 - $2,870
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