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Biovision

  • B-Raf Inhibitor 1

    Biovision | B-Raf Inhibitor 1 | 2599

    B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC₅₀s of 0.31 µM and 2 nM for A375 proliferation and A375 p-ERK respectively.B-Raf inhibitor 1 is a potent and selective B-Raf...

    $1,008 - $3,070
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  • Compound E

    Biovision | Compound E | 1949

    Cell-permeable. A potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC₅₀ = 0.3 nM for total β-amyloid) and Notch processing. At higher concentrations (20-400 µM),...

    $837 - $1,985
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  • Bexarotene

    Biovision | Bexarotene | 1575

    Bexarotene is a synthetic retinoid analog with specific affinity for the retinoid X receptor and belongs to a group of compounds called rexinoids. It is an oral, noncytotoxic drug that was approved...

    $865 - $2,065
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  • Zileuton

    Biovision | Zileuton | B2314

    A potent and reversible 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis (IC₅₀ values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively).Zileuton is a potent and...

    $949 - $2,898
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  • CCG-1423

    Biovision | CCG-1423 | 9434

    CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. CCG-1423 displays activity in several in vitro cancer cell functional...

    $777 - $2,209
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  • UNC0642

    Biovision | UNC0642 | 2862

    UNC0642 is a potent, selective and cell-permeable inhibitor of G9a (EHMT2) and GLP (EHMT1) histone lysine methyltransferases. UNC0642 exhibits an in vitro IC₅₀ 100-fold over 13 other HMTs and...

    $1,120 - $3,584
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  • ZCL278

    Biovision | ZCL278 | 2466

    Cell-permeable. A selective CDc42 GTPase inhibitor. It specifically targets Cdc42-ITSN interaction and inhibits Cdc42-mediated cellular processes; could be a valuable tool to explore Cdc42’s...

    $949 - $2,898
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  • GLPG0634 Analog

    Biovision | GLPG0634 Analog | B1836

    GLPG0634 analog is a potent and selective JAK1 inhibitor with IC₅₀ values of 10, 28, 810, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.GLPG0634 analog is a potent and selective JAK1...

    $949 - $2,870
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  • MS436

    Biovision | MS436 | 2680

    MS436 is a potent and selective BRD4 bromodomain inhibitor (Ki = 30-50 nM for BrD1). It displays 10-fold selectivity for BrD1 of BRD4 over BrD2 of BRD4.MS436 is a potent and selective BRD4...

    $949 - $2,930
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  • Pioglitazone

    Biovision | Pioglitazone | 1877

    Cell-permeable. A thiazolidinedione (TZD) derivative that acts as a selective peroxisome proliferator-activated receptor gamma (PPARγ) agonist (EC₅₀ = 0.69 μM). An antidiabetic agent; improves...

    $637 - $4,046
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  • SRPIN340

    Biovision | SRPIN340 | 2458

    An ATP-competitive, serine/arginine-rich protein kinase (SRPK)-specific inhibitor (Ki = 0.89 µM for SRPK1). SRPIN 340 does not inhibit other classes of Serine-Arginine-Rich Protein Kinases (SRPKs)...

    $949 - $2,898
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  • 1-NM-PP1

    Biovision | 1-NM-PP1 | B2346

    1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. Inhibits multiple tyrosine kinase targets, such as v-Src (IC50...

    $777 - $2,209
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  • PND-1186

    Biovision | PND-1186 | 2823

    PND-1186 is a potent FAK (Focal adhesion kinase) inhibitor (IC₅₀ = 1.5 nM) with potential antineoplastic activity. PND-1186 inhibits FAK, blocks fibronectin-stimulated FAK autophosphorylation of...

    $1,008 - $3,129
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  • IWP-2

    Biovision | IWP-2 | 1962

    Cell-permeable. Acts as an inhibitor of Wnt secretion and processing. It blocks Wnt-dependent signaling (IC₅₀ = 27 nM) by inhibition of the O-acyltransferase Porcn. Porcn is a member of the...

    $1,036 - $3,273
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  • RGFP966

    Biovision | RGFP966 | 2818

    RGFP966 is a potent and selective histone deacetylase 3 (HDAC3) inhibitor (IC₅₀ = 80 nM). It does not inhibit other HDACs at concentrations up to 15 µM.RGFP966 is a potent and selective histone...

    $837 - $2,440
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  • WHI-P154

    Biovision | WHI-P154 | 2659

    WHI-P154 is a potent JAK3 inhibitor (IC₅₀ of 1.8 μM). It displays no activity against JAK1 or JAK2. Also inhibits EGFR, Src, Abl, VEGFR and MAPK, and prevents Stat3, but not Stat5 phosphorylation...

    $718 - $1,985
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  • PF-4989216

    Biovision | PF-4989216 | B1659

    PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216 inhibits PI3Kalpha (Ki=0.6 nM) and mTOR (Ki=1440 nM).PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216...

    $1,120 - $3,385
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  • BPTU

    Biovision | BPTU | B2323

    An allosteric P2Y1 antagonist. Prevents inhibition of spontaneous contraction of rat and mouse colon induced by electrical field stimulation, nicotine and P2Y agonists. Acts as n antithrombotic agent...

    $837 - $2,440
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  • Epoxomicin

    Biovision | Epoxomicin | 2190

    Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent...

    $837 - $2,671
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  • MK-8745

    Biovision | MK-8745 | B1942

    MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.MK-8745 is a novel Aurora-A specific...

    $837 - $2,440
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  • Stattic

    Biovision | Stattic | 2625

    Stattic is a small molecule that selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2...

    $718 - $1,985
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  • KY02111

    Biovision | KY02111 | 2264

    Promotes cardiac differentiation of human pluripotent stem cells (hPSCs) and human embryonic stem cells (hESCs) into cardiomyocytes. KY02111 promotes differentiation by inhibiting WNT signaling in...

    $665 - $1,754
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  • BMS-833923

    Biovision | BMS-833923 | 9547

    BMS-833923 is a potent inhibitor of Smo (Smoothened) with potential antineoplastic activity. It blocks binding of BODIPY cyclopamine (IC₅₀ = 21 nM) and inhibits Gli activation in cell lines that...

    $949 - $2,898
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  • UNC0646

    Biovision | UNC0646 | 2606

    UNC0646 is a potent and selective inhibitor of protein lysine methyltransferases G9a and GLP activities in vitro (IC₅₀s = 6 and 15 nM, respectively) ; inhibits G9a/GLP-mediated dimethylation of...

    $1,061 - $3,129
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  • XL388

    Biovision | XL388 | B1733

    XL388 is a potent and selective inhibitor of mTOR with IC50 value of 9.9 nM.XL388 is a potent and selective inhibitor of mTOR with IC50 value of 9.9 nM.Biovision | B1733 | XL388 DataSheetAlternate...

    $837 - $1,866
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  • PP2

    Biovision | PP2 | 1767

    An inhibitor of the Src family of kinases. Inhibits Src and Lck kinase with IC₅₀ values of 36 nM and 31 nM respectively. Also shown to inhibit RIP2( IC₅₀ = 19 nM) and CK1δ (IC₅₀ = 41 nM).PP2 is an...

    $865 - $2,499
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  • PP1

    Biovision | PP1 | 1927

    Cell-permeable. A potent Src-selective tyrosine kinase (TK) inhibitor. Inhibits p56lck and p59fynT (IC₅₀ values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2...

    $665 - $1,463
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  • SC-514

    Biovision | SC-514 | 2442

    A reversible, competitive inhibitor of IKK2 (IC₅₀ = 11.2 µM). Does not inhibit other IKK isoforms, or other kinases. Displays dose-dependent inhibition of the transcription of NK-κB dependent genes...

    $718 - $1,985
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  • XL019

    Biovision | XL019 | 2609

    XL019 is a potent, highly selective and reversible JAK2 inhibitor (IC₅₀ = 2.2 nM). Inhibits JAK1 (IC₅₀ = 134.3 nM), JAK3 (IC50 = 214.2 nM) and TYK2 (IC₅₀ = 348.3 nM) at higher concentrations. XL019...

    $837 - $2,440
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  • Motolimod

    Biovision | Motolimod | B1594

    Motolimod (VTX-2337) is a potent and selective, small molecule Toll-like receptor (TLR) 8 agonist (EC₅₀ = 100 nM) that stimulates natural killer (NK) cells, dendritic cells, and monocytes. Useful in...

    $1,008 - $3,129
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  • TAS-103

    Biovision | TAS-103 | B1841

    TAS-103 (BMS-247615) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topo II).TAS-103 (BMS-247615) is a dual inhibitor of topoisomerase-I (topo-I) and topoisomerase-II (topo II)...

    $1,008 - $3,129
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  • Streptozocin

    Biovision | Streptozocin | 1930

    An antitumor antibiotic. Acts as a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Also acts as a diabetagen,and is especially toxic to pancreatic islet...

    $690 - $1,754
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  • Ebselen

    Biovision | Ebselen | 2169

    An organo-selenium compound that displays potent antioxidant properties. Acts as a glutathione peroxidase (GPX) mimic as well as being an excellent scavenger of peroxynitrite. The glutathione...

    $637 - $1,582
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  • Resiquimod

    Biovision | Resiquimod | 1699

    A selective ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in humans. Displays antitumor and antiviral properties. Stimulates antibody secretion, cytokine production,...

    $777 - $1,523
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  • Pirarubicin

    Biovision | Pirarubicin | B2216

    Pirarubicin is an analog of doxorubicin, that acts as an antineoplastic drug. Pirarubicin is transported into cells via a sodium-dependent nucleoside transporter. It is used to intercalate DNA and...

    $1,120 - $3,584
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  • Pimecrolimus

    Biovision | Pimecrolimus | 1593

    Pimecrolimus is a cell-selective inhibitor of inflammatory cytokines developed for the treatment of inflammatory skin diseases, such as allergic contact dermatitis, atopic dermatitis, plaque-type...

    $1,036 - $1,887
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  • Nedaplatin

    Biovision | Nedaplatin | 1576

    Nedaplatin is an analog of platinum-based anti-cancer drugs such as carboplatin and cisplatin. It has cytotoxic activity in human ovarian tumors. The administration of either nedaplatin or cisplatin...

    $1,463
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  • MSX-122

    Biovision | MSX-122 | B2276

    MSX-122 is a potent inhibitor of CXCR4 with potential antineoplastic and antiviral activities.MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1)...

    $777 - $2,156
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  • Gö 6983

    Biovision | Gö 6983 | 9539

    Gö 6983 is a broad-spectrum Protein Kinase C (PKC) inhibitor; inhibits several isoforms of protein kinase C with IC₅₀ values of 7, 7, 6, 10, 60, and 20,000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ, and...

    $777 - $2,209
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  • Mifepristone

    Biovision | Mifepristone | 1561

    Progesterone receptor antagonist; stimulates prolactin secretion. Also acts as Pgp inhibitor.Mifepristone is a progesterone receptor antagonist; stimulates prolactin secretion. Also acts as Pgp...

    $1,488
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  • Meisoindigo

    Biovision | Meisoindigo | B1822

    Meisoindigo is a synthetic derivative of indirubin that acts as a potential agent for acute myeloid leukemia. In the in vitro assay, it can inhibit synthesis of DNA and RNA and the assembly of...

    $1,152 - $3,675
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  • LW6

    Biovision | LW6 | B2277

    LW6 is a potent HIF-1 inhibitor (IC₅₀ = 4.4 μM). It promotes proteasomal degradation of HIF-1α via upregulation of von-Hippel-Landau (VHL) without affecting the activity of prolyl hydroxylase (PHD)...

    $837 - $2,440
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  • Lomeguatrib

    Biovision | Lomeguatrib | 2224

    Lomeguatrib is a potent inhibitor of DNA repair protein O6-Methylguanine-DNA methyltransferase (MGMT) and related mammalian proteins. PaTrin-2 displays nanomolar activity in vitro and in vivo...

    $665 - $1,754
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  • Daminozide

    Biovision | Daminozide | 2438

    A highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC₅₀ values of 1.5, 0.55, and 2.1 μM, respectively. When tested for inhibition of...

    $665 - $1,351
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  • GDC-0152

    Biovision | GDC-0152 | B1602

    GDC-0152 is a potent small molecule antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively; less affinity shown to cIAP1-BIR2 and...

    $1,411 - $4,158
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  • Ganciclovir

    Biovision | Ganciclovir | 1918

    An acyclic analog of the nucleoside guanosine, chemically related to acyclovir. It inhibits the replication of viruses including CMV, Herpes Simplex, Varicella Zoster and Epstein-Barr. It inhibits...

    $851 - $4,648
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  • Fulvestrant

    Biovision | Fulvestrant | B1863

    Fulvestrant is a high affinity estrogen receptor antagonist (IC₅₀ = 0.29 nM), that works by down-regulating and degrading the estrogen receptor, ERα. Reported to lack any partial agonist activity...

    $1,008 - $3,129
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  • Ezatiostat

    Biovision | Ezatiostat | 2608

    Ezatiostat is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity. After intracellular de-esterification, the...

    $837 - $2,440
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