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Biovision

  • QS11

    Biovision | QS11 | 1680

    Inhibits the GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) as well as synergizes the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway regulates cell fate and...

    $1,351
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  • ML141

    Biovision | ML141 | 2267

    Cell-permeable. A potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPase (IC₅₀ = 2.6 and 5.4 μM for Cdc42 wild type and activated mutant, respectively). No appreciable inhibitory...

    $777 - $2,555
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  • genz-123346

    Biovision | genz-123346 | B2286

    Genz-123346 is a potent and selective glucosylceramide synthase inhibitor with potential anticancer activity. Does not affect the activities of other related glycosidase, such as 1-O-acylceramide...

    $777 - $2,296
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  • Tautomycin

    Biovision | Tautomycin | B1237

    Tautomycin is a potent protein phosphatase inhibitor that inhibits PP1 completely at 3 nM and PP2 at 30 nM. Acts as a weak inhibitor of PP2B and does not inhibit PP2C. Its cell permeability and...

    $1,239 - $4,018
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  • Liproxstatin-1

    Biovision | Liproxstatin-1 | B2312

    A potent inhibitor of ferroptosis. Liproxstatin-1 suppresses ferroptosis in human cells and in an ischemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4)...

    $777 - $2,209
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  • ITD-1

    Biovision | ITD-1 | 2879

    ITD-1 is a potent and highly selective TGFβ pathway inhibitor (IC₅₀ = 0.85 µM). ITD-1 promotes cardiomyocyte differentiation specifically via degradation of the TGFβ type II receptor (TGFBR2),...

    $1,061 - $3,357
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  • 10058-F4

    Biovision | 10058-F4 | 2739

    10058-F4 is a c-Myc inhibitor that inhibits the c-Myc-Max associationn and function. It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse...

    $777 - $2,209
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  • CH-223191

    Biovision | CH-223191 | 2723

    CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. It blocks activation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (IC₅₀ = 0.03 µM). It also blocks TCDD-mediated...

    $777 - $2,209
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  • BPTES

    Biovision | BPTES | B2165

    BPTES is an allosteric glutaminase (GLS1) inhibitor (IC₅₀ = 3.3 μM). Displays selectivity for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro...

    $949 - $2,898
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  • Entrectinib

    Biovision | Entrectinib | B1324

    Entrectinib is an inhibitor of TrkA (IC₅₀ = 1.7 nM), TrkB (IC₅₀ = 0.1 nM), and TrkC (IC₅₀ = 0.1 nM), as well as C-ros oncogene 1 (ROS1; IC₅₀ = 0.2 nM) and anaplastic lymphoma kinase (ALK; IC₅₀ = 1.6...

    $1,008 - $3,129
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  • MPI-0479605

    Biovision | MPI-0479605 | 9589

    MPI-0479605 is a potent, selective, ATP-competitive small-molecule inhibitor of the Mitotic kinase Mps1 (IC₅₀ = 1.8 nM).MPI-0479605 is a potent, selective, ATP-competitive small-molecule inhibitor of...

    $1,008 - $3,129
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  • Acalisib

    Biovision | Acalisib | B1666

    Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM.Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM.Biovision | B1666...

    $865 - $2,587
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  • URMC-099

    Biovision | URMC-099 | 9443

    URMC-099 is a brain-permeable, mixed lineage kinase (MLK) inhibitor with IC₅₀ values of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. In vitro, URMC-099 treatment...

    $949 - $2,898
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  • A-366

    Biovision | A-366 | 2859

    A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC₅₀ = 3.3 nM). It displays >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. A-366 has been...

    $889 - $2,499
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  • Velpatasvir

    Biovision | Velpatasvir | B1194

    Velpatasvir (formerly GS-5816) is a novel NS5A inhibitor that has potent in vitro anti-HCV activity across all genotypes at the picomolar level.Velpatasvir (formerly GS-5816) is a novel NS5A...

    $777 - $2,209
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  • RO-3306

    Biovision | RO-3306 | 2039

    Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells. Actively enhances downstream p53 signaling to...

    $690 - $1,813
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  • Pyridoclax

    Biovision | Pyridoclax | B1817

    Pyridoclax(MR-29072) is a potent Mcl-1 inhibitor (Kd = 25 nM). Pyridoclax is able to disrupt BimL/Mcl-1 interaction in whole living cells.Pyridoclax(MR-29072) is a potent Mcl-1 inhibitor (Kd = 25 nM)...

    $1,061 - $3,385
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  • Bikinin

    Biovision | Bikinin | 2034

    Cell-permeable. A highly specific inhibitor for the 7 Arabidopsis GSK-3 like kinase that activates brassinosteroid (BR) signaling downstream of the BR receptor. Bikinin directly binds the GSK3 BIN2...

    $690 - $1,813
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  • OF-1

    Biovision | OF-1 | 9592

    OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd values are 100 and 500 nM respectively). OF-1 displays 39-fold selectivity for BRPF1B and BRPF2 over BRD4. It increases thermal...

    $1,120 - $3,584
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  • LY3023414

    Biovision | LY3023414 | B1759

    LY3023414 is a small molecule that has been shown in vitro to be a selective ATP-competitive inhibitor of PI3Kα and mTOR, DNA-PK, and other class I PI3K family members.LY3023414 is a small molecule...

    $718 - $1,985
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  • SKF-86002

    Biovision | SKF-86002 | 2894

    SKF-86002 is a p38 MAP kinase inhibitor (IC₅₀ = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC₅₀ = 1 μM). Also acts as an inhibitor of both cyclooxygenase...

    $1,120 - $3,532
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  • GV-58

    Biovision | GV-58 | 2616

    GV-58 is a Roscovitine (Cat. No. 1950) derivative that acts as a selective N- and P/Q-type Ca²⁺-channel agonist. These Ca2²⁺-channels regulate transmitter release in synapses. Potential lead compound...

    $837 - $2,440
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  • ANA-12

    Biovision | ANA-12 | 2878

    ANA-12 is a potent and selective TrkB antagonist that prevents activation of the receptor by BDNF with a high potency. It binds selectively to TrkB and inhibits processes downstream of TrkB without...

    $1,061 - $3,357
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  • NS-1619

    Biovision | NS-1619 | B1303

    NS-1619 is a calcium-dependent activator of large-conductance Ca²⁺-activated K⁺ (BKCa) channels in vascular smooth muscle. Induces a concentration-dependent decrease in mitochondrial membrane...

    $949 - $2,727
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  • PF-06447475

    Biovision | PF-06447475 | 9447

    PF-06447475 is a highly potent, selective, brain-permeable, and in vivo active LRRK2 (Leucine rich repeat kinase 2) kinase inhibitor. Could be potentially useful in the treatment of Parkinson’s...

    $837 - $2,440
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  • OTS-964

    Biovision | OTS-964 | B1964

    OTS-964 is a potent inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC₅₀ = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of...

    $1,120 - $3,584
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  • Z-DEVD-FMK

    Biovision | Z-DEVD-FMK | 1143

    A synthetic peptide that irreversibly inhibits activity of DEVD-dependent caspases (e.g., caspase-3 and caspase-7) and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell...

    $1,694 - $4,277
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  • WS3

    Biovision | WS3 | 2799

    WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM (induced R7T1 proliferation). More recently, WS3 has been found to mediate proliferation of primary retinal pigment...

    $837 - $2,440
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  • WS6

    Biovision | WS6 | 2711

    WS6 is a novel Inducer of β cell proliferation. Inthe RIP-DTA mouse model of β cell ablation, WS6 normalizes blood glucose and induces concomitant increases in β cell proliferation and β cell number...

    $837 - $2,440
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  • Y15

    Biovision | Y15 | B1252

    Y15 is a selective focal adhesion kinase (FAK) inhibitor preventing FAK autophosphorylation at IC₅₀ of 1 μM. It does not have any significant activity against a range of other kinases like EGFR,...

    $777 - $1,985
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  • Gilteritinib

    Biovision | Gilteritinib | B1294

    Gilteritinib is a potent FLT3 (FMS-like tyrosine kinase 3) inhibitor which shows potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.Gilteritinib is a potent...

    $949 - $2,898
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  • Zotarolimus

    Biovision | Zotarolimus | 9530

    Zotarolimus is a semi-synthetic derivative of Sirolimus (Cat. No. 1568) that acts as an immunosuppressant. Zotarolimus displays meachanism similar to sirolimus in having high-affinity binding to the...

    $1,008 - $3,129
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  • PFI-3

    Biovision | PFI-3 | 2895

    PFI-3 is a potent and selective polybromo 1 (PB1) and SMARCA4 (SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily A, member 4) inhibitor (Kd values are 48 and 89 nM...

    $1,120 - $3,584
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  • BAY 41-2272

    Biovision | BAY 41-2272 | 9429

    BAY 41-2272 is a soluble guanylyl cyclase (sGC) activator; acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC₅₀ = 36 nM) and...

    $1,008 - $3,129
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  • Ro 61-8048

    Biovision | Ro 61-8048 | 1912

    Cell-permeable. A high-affinity small molecule inhibitor of KMO (kynurenine 3-monoxygenase or kynurenine 3-hydroxylase)(Ki = 4.8 nM, IC₅₀ = 37 nM).Ro 61-8048 is a high-affinity small molecule...

    $865 - $4,375
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  • UNC0379

    Biovision | UNC0379 | 9588

    UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SET8 (IC₅₀ = 7.3 µM; Kd = 18.3 µM). It is selective for SET8 over 15 other methyltransferases, including G9a...

    $1,008 - $3,129
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  • HTH-01-015

    Biovision | HTH-01-015 | 2887

    HTH-01-015 is a potent and selective inhibitor of NUAK1 kinase (IC₅₀ =100 nM); only weakly inhibits NUAK2 (IC₅₀ of >10 μM) and does not significantly inhibit the activity of 139 other kinases that...

    $1,239 - $4,018
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  • G-749

    Biovision | G-749 | B2213

    G-749 is a potent FLT3 kinase inhibitor that displays potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD, FLT3-D835Y, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular...

    $718 - $1,866
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  • (-)-Indolactam V

    Biovision | (-)-Indolactam V | 2197

    Cell-permeable. A protein kinase C (PKC) activator and a tumor promoter. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.(-)-Indolactam is a protein kinase C...

    $921 - $2,156
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  • Q-VD-OPh

    Biovision | Q-VD-OPh | 1170

    A synthetic peptide that is potent, cell permeable, nontoxic and irreversibly inhibits caspase activity to blocks apoptosis. The new generation of caspase inhibitor is more stable in aqueous...

    $1,323 - $37,989
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  • OAC1

    Biovision | OAC1 | B1079

    OAC1 is an Oct4-activating compound that activates expression through the Oct4 gene promoter. In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC1 (1 μM) enhances reprogramming efficiency by...

    $837 - $2,440
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  • Kenpaullone

    Biovision | Kenpaullone | 1904

    Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases. In addition, it has been found to be a...

    $749
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  • WH-4-023

    Biovision | WH-4-023 | 2827

    WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC₅₀ of 2 nM and 6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.WH-4-023 is a potent and selective dual...

    $1,120 - $3,644
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  • IM-12

    Biovision | IM-12 | 2822

    IM-12 is a potent and selective GSK-3β inhibitor (IC₅₀ = 53 nM). It significantly increases β-catenin levels, leads to TCF-induction and promotes neuronal differentiation in human neural progenitor...

    $777 - $2,268
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  • Ozanimod

    Biovision | Ozanimod | B1196

    Ozanimod (RPC1063) is an orally bioavailable agonist of the sphingosine-1-phosphate receptor subtypes 1 (S1P1) and 5 (S1P5). S1P receptors belong to the family of G-protein-coupled receptor which...

    $1,120 - $3,413
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  • YH239-EE

    Biovision | YH239-EE | B1229

    YH239-EE is potent p53-MDM2 interaction inhibitor that induces cell cycle arrest leading to potential apoptosis by p53 activation and downstream target in AML cells with p53 mutationYH239-EE is...

    $1,008 - $3,129
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  • Serabelisib

    Biovision | Serabelisib | B1930

    Serabelisib is a potent inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is selective for p110α in vitro (IC₅₀ = 15 nM for PI3Kα vs. >1 µM for other isoforms, as well as for mTOR). MLN1117...

    $1,008 - $3,129
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  • K02288

    Biovision | K02288 | B2321

    A potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC₅₀ values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5...

    $837 - $2,440
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  • DMH-1

    Biovision | DMH-1 | 9542

    DMH-1 is an analog of Dorsomorphin (Cat. No. 1686) that acts as a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH-1 exclusively targets the BMP but not the VEGF pathway. Blocks...

    $1,008 - $3,273
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  • T-5224

    Biovision | T-5224 | 9546

    T-5224 is a selective inhibitor of c-Fos/activator protein (AP)-1 that ameliorates liver injury and improves survival through decreasing production of pro-inflammatory cytokines and chemokines in...

    $1,180 - $3,644
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  • XEN445

    Biovision | XEN445 | 2681

    XEN445 is a potent and selective endothelial lipase (EL) inhibitor. It displays good ADME and PK properties and shows in vivo efficacy in raising plasma HDL cholesterol concentration in mice.XEN445...

    $949 - $2,930
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  • PI-3065

    Biovision | PI-3065 | B1674

    PI-3065 is a small molecule and selective inhibitor of p110δkinase with an Ki value of 1.5nM and IC50 value of 5nM.PI-3065 is a small molecule and selective inhibitor of p110δkinase with an Ki value...

    $865 - $2,699
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