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Biovision | MK-4827 | 9462

MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumour models with loss of BRCA and...

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Biovision | MK-3102 | 9599

MK-3102 is a potent, selective and long-acting dipeptidyl peptidase-4 (DPP-4) inhibitor with IC₅₀ of 1.6 nM; highly selective over other proteases (QPP, DPP8, and FAP) tested.MK-3102 is a potent,...

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Biovision | MK-2206 | 1888

A highly selective non-ATP competitive allosteric Akt inhibitor with IC₅₀’s of 8 nM, 2 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr³⁰⁸ and...

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Biovision | MK-1775 | 2373

MK-1775 is a potent and selective inhibitor of the tyrosine kinase WEE1 (IC₅₀ = 5.2 nM). It selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1...

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Biovision | MK-1439 | B1250

MK-1439 (also known as Doravirine), is a non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT), K103N and...

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Biovision | MK-0941 | B1207

MK-0941 is selective, allosteric glucokinase activator (GKA) that activates glucokinase (hexokinase subtype IV) with greater selectivity than over different hexokinase isoforms. MK-0941 shows...

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Biovision | Mito-TEMPO (hydrate) | 9486

Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties. Mitochondrial targeting of superoxide scavenging using mito-TEMPO...

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Biovision | Mitiglinide calcium | B2108

Mitiglinide calcium is a highly selective potassium channel blocker that stimulates insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic beta-cells. Mitiglinide is a...

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Biovision | Mithramycin A | B1532

Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or...

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Biovision | Minocycline Hydrochloride | B1525

Minocycline is a broad-spectrum, brain-permeable, tetracycline antibiotic that displays neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Acts as a matrix metalloproteinase...

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Biovision | Migalastat hydrochloride | B2404

Migalastat hydrochloride is a pharmacological chaperone that acts as a selective and competitive inhibitor of α-galactosidase (IC₅₀ = 40 nM). At subinhibitory concentrations,...

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Biovision | Microcystin-LR | 1840

A hepatotoxic cyclic heptapeptide toxin produced by cyanobacteria. A selective inhibitor of protein phosphatase 1 (PP1) (IC₅₀ = 1.7 nM) and protein phosphatase 2A (PP2A) (IC₅₀ = 0.04 nM). Less...

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Biovision | Micafungin sodium | 2585

Micafungin is an antifungal drug that belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component...

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Biovision | MGCD0103 | 2633

MGCD0103 (Mocetinostat) is a class I selective HDAC inhibitor that inhibits HDAC1, HDAC2 and HDAC3 with IC₅₀ values of 0.15, 0.29 and 1.66 µM, respectively. Displays anticancer activities.MGCD0103...

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Biovision | MG-115 | 1831

A potent, reversible proteasome inhibitor with Ki of 21 nM for 20S proteasome and 35 nM for 26S proteasome. The inhibition of proteasome was through specific inhibition of chymotrypsin-like activity...

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Biovision | MF-438 | B1178

MF-438 is a potent, cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1) with an IC₅₀ of 2.3 nM.MF-438 is a potent, cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1) with an IC₅₀...

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Biovision | Methoxy-X04 | 2664

Methoxy-X04 is a derivative of Congo Red (Cat. No. 2588) and Chrysamine G that acts as a fluorescent probe for the detection of amyloid self-assembly in vitro and in vivo. It stains plaques, tangles,...

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Biovision | MEK-162 | 2254

Cell-permeable. A potent, non-ATP competitive inhibitor of MEK1/2 (IC₅₀ = 12 nM) and cellular pERK (IC₅₀ = 11 nM). Selective against a panel of other 220 kinases (displays no activity even at 10 µM)...

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Biovision | Megestrol acetate | B2193

Megestrol acetate is a synthetic derivative of the naturally occurring female sex hormone progesterone, with progestogenic, antiestrogenic, and antineoplastic activities. Also acts as an appetite...

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Biovision | Mefloquine hydrochloride | B2169

Mefloquine hydrochloride is a phospholipid-interacting antimalarial drug that is very effective against Plasmodium Falciparum with very few side effects.Mefloquine hydrochloride is a...

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Biovision | Medroxyprogesterone 17-acetate | B2192

Medroxyprogesterone 17-acetate is a synthetic progestogen that blocks fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when...

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Biovision | ME-0328 | 2751

ME-0328 is a potent and selective PARP-3 inhibitor (IC₅₀ = 0.89 µM). ME-0328 inhibits PARP-1, PARP-2 and other ARDTs (ADP ribosyltransferases) at much higher concentrations (IC₅₀ = 6.3, 10.8 and >30...

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Biovision | MDV-3100 | 9479

MDV-3100 (Enzalutamide) is an androgen-receptor (AR) antagonist (IC₅₀ = 36 nM). Prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been...

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Biovision | MDL 28170 | 2195

A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates...

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Biovision | MDK-7933 | B2119

MDK-7933 is a potent HDAC8 inhibitor with an IC₅₀ of 27.2 nM in cancer cell lines. MDK-7933 displays antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5)...

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Biovision | Mdivi -1 | 2441

Cell-permeable. A selective inhibitor of Dnm1 GTPase (IC₅₀ =1-10 µM). Inhibits mitochondrial outer membrane permeabilization. Inhibits mitochondrial division and apoptosis.Mdivi-1 is a selective...

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Biovision | MDBN | 2033

Cell-permeable. An irreversible inhibitor of p97 (IC₅₀

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Biovision | MCC950 sodium | 9686

MCC950 sodium is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1,...

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Biovision | MCC950 (Free base) | B1031

MCC950 is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4,...

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Biovision | MCB613 | B2268

MCB-613 is a small-molecule steroid coactivators SRC-1, SRC-2, and SRC-3 that has been used to disrupt cancer cell homeostatic dependence on SRCs. MCB-613 can super-stimulate SRCs’ transcriptional...

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Biovision | Mca-RPPGFSAFK(Dnp) | B1132

A useful fluorescence resonance energy transfer (FRET) substrate for assaying ECE-1 and ECE-2, ACE1 and ACE2. neprilysin, thermolysin (TLN), MMP-2 and MMP9, thimet oligopeptidase, cathepsin A,...

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Biovision | MC-1568 | B1085

MC-1568 is a selective class II (IIa) histone deacetylase (HDAC II) inhibitor (IC₅₀ = 220 nM). It displays >170-fold selectivity over class I HDACs, including HDAC1.MC-1568 is a selective class II...

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Biovision | MBX-8025 | B1997

MBX-8025 is a selective peroxisome proliferator-activated receptor (PPAR) -δ agonist. MBX-8025 may have potential use for the treatment of dyslipidemia, metabolic syndrome, type 2 diabetes, and...

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Biovision | Mavacoxib | B1988

Mavacoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent and selective cyclooxygenase-2 (COX-2) inhibitor. Displays anti-inflammatory properties. Useful for treatment of dogs...

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Biovision | Maraviroc | B2044

Maraviroc is a potent and selective C-C chemokine receptor type 5 (CCR5) antagonist drug that is designed to act against HIV by interfering with the interaction between HIV and CCR5. Maraviroc is a...

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Biovision | Manumycin A | 2333

An antibiotic Isolated from Streptomyces parvulus. A Potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC₅₀ = 30 nM). Does not affect...

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Biovision | Mambalgin-1 | 2421

Mambalgin-1 is a peptide toxin originally isolated from the venom of Black Mamba (Dendroaspis polylepis polylepis). Acts as an analgesic. Mambalgin-1 is able to abolish pain through inhibition of...

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Biovision | MALT1 Inhibitor, MI-2 | B2368

MALT1 inhibitor MI-2 is a potent inhibitor of the paracaspase MALT1 (Mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) (IC₅₀ = 5.84 μM). MI-2 binds directly to MALT1 and irreversibly...

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Biovision | MAK-683 | B1972

MAK-683 is a potent EED (embryonic ectoderm development protein) inhibitor and an allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. MAK683...

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Biovision | M-3814 Nedisertib | B2217

Biovision | M-3814 Nedisertib | B2217

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Biovision | Lys01 trihydrochloride | B2117

Lys01 trihydrochloride (Lys05) is a potent, water-soluble lysosomal autophagy inhibitor with IC₅₀ values of 3.6, 3.8, 6 and 7.9 μM for 1205Lu, c8161, LN229 and HT-29 cell line in the MTT assay.Lys01...

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Biovision | LY-83583 | B1314

LY-83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC₅₀ value of 2 µM. Also blocks the release of...

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Biovision | LY573636 | 2297

A potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism...

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Biovision | LY404187 | 2698

LY404187 is a selective, potent and centrally active positive allosteric modulator of AMPA receptors. It preferentially acts at recombinant human homomeric GluR2 and GluR4 versus GluR1 and GluR3 AMPA...

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Biovision | LY364947 | 2646

LY364947 is a selective inhibitor of TGF-β RI (TGFR-I, TβR-I, ALK-5), with an IC₅₀ value of 59 nM. LY364947 only weakly inhibits TGF-β RII (IC₅₀ = 400 nM), p38 MAPK (IC₅₀ = 740 nM), and mixed lineage...

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Biovision | LY-341495 | 2875

LY341495 is a potent, brain-permeable, and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC₅₀s = 21 and 14 nM, respectively, for human isoforms)...

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Biovision | LY-333,531 hydrochloride | 2156

An isozyme-selective inhibitor of protein kinase Cβ (PKCβ). Inhibits both the PKCβI (IC₅₀ = 4.7 nM) and PKCβII (IC₅₀ = 5.9 nM) isozymes. LY-333,531 is 76- and 61-fold more selective for inhibition of...

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Biovision | LY-3200882 | B2350

LY-3200882 is a potent and ATP-competitive inhibitor of TGF-β receptor type 1 (TGF-βRI). It inhibits TGF-β-induced SMAD phosphorylation in vitro and in vivo and exhibits antitumor activity in the...

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Biovision | LY315920 | 2666

LY315920 is a potent, and selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2) (IC₅₀ = 9± 1 nM). Potential anti-inflammatory agent.LY315920 is a potent, and...

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Biovision | LY-310762 hydrochloride | B2190

LY-310762 is a potent antagonist of the serotonin (5-HT) receptor subtype 5-HT1D (Ki = 249 nM for guinea pig receptors). It is selective for 5-HT1D over the 5-HT1B receptor, where it inhibits binding...

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Biovision | LY-2940680 | 9604

LY-2940680 binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling pathway. Displays anticancer properties.LY-2940680 binds to the Smoothened (Smo) receptor and potently...

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Biovision | LY-2874455 | 9532

LY-2874455 is a potent, FGF/FGFR inhibitor. Exhibits potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in...

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