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Biovision

  • GLPG-1690

    Biovision | GLPG-1690 | B1850

    GLPG-1690 is a selective autotaxin inhibitor with potential application in idiopathic pulmonary disease (IPF).GLPG-1690 is a selective autotaxin inhibitor with potential application in idiopathic...

    €813 - €2,484
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  • GKT-137831

    Biovision | GKT-137831 | 9444

    GKT-137831 is a novel pyrazolopyridinedione derivative that acts as a Nox4 and Nox1 inhibitor ((Ki 100–150 nM). GKT-137831 attenuates hypoxia-induced pulmonary vascular cell proliferation. Also a...

    €960 - €2,682
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  • GFT505

    Biovision | GFT505 | B1030

    GFT505 (Elafibranor) is a novel liver-targeted peroxisome proliferator-activated receptor alpha/delta (PPARα/δ) agonist. Displays anti-diabetic effects in db/db mice.GFT505 (Elafibranor) is a novel...

    €960 - €3,072
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  • Geodin

    Biovision | Geodin | 9685

    Geodin is a Plasmigen activator inhibitor (PAI-1) inhibitor and Glucose uptake stimulator.Geodin is a Plasmigen activator inhibitor (PAI-1) inhibitor and Glucose uptake stimulator.Biovision | 9685 |...

    €1,062 - €3,321
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  • GDC0994

    Biovision | GDC0994 | B1629

    GDC-0994 is highly selective inhibitor of extracellular signal-regulated kinase (ERK), ERK1 and ERK2, with biochemical potency of 1.1 nM and 0.3 nM, respectively.GDC-0994 is highly selective...

    €936 - €2,925
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  • GDC-0980

    Biovision | GDC-0980 | 2668

    GDC-0980, a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2). It inhibits PI3Kα/β/δ/γ with IC₅₀ values of 5 nM/27 nM/7 nM/14 nM, respectively and mTOR...

    €666 - €1,893
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  • GDC-0941

    Biovision | GDC-0941 | 1623

    GDC-0941 is a potent inhibitor of p110α and p110δ (IC₅₀ = 3 nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger...

    €987 - €2,805
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  • GDC-0917

    Biovision | GDC-0917 | B1918

    GDC-0917 (CUDC-427) is a second mitochondrial activator of caspases (Smac) mimetic, a small molecule inhibitor, that mimics Smac, an endogenous antagonist of IAP proteins. GDC-0917 binds to the Smac...

    €666 - €1,893
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  • GDC0879

    Biovision | GDC0879 | B1340

    A novel, potent, and selective inhibitor of B-Raf with an IC50 value of 0.13 nMA novel, potent, and selective inhibitor of B-Raf with an IC50 value of 0.13 nMBiovision | B1340 | GDC0879...

    €1,209 - €3,564
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  • GDC-0853

    Biovision | GDC-0853 | B2074

    GDC-0853 is a potent and selective, Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. GDC-0853 suppresses B cell- and myeloid cell-mediated components of disease and...

    €1,011 - €3,321
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  • GDC-0449

    Biovision | GDC-0449 | 1890

    A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes...

    €888 - €2,805
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  • GDC-0068

    Biovision | GDC-0068 | 2667

    GDC-0068 is a potent, ATP-competitive, pan-Akt inhibitor with IC₅₀s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively. Displays selectivity over more than other 200 screened kinases. Potential...

    €717 - €2,091
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  • GDC-0032

    Biovision | GDC-0032 | 9573

    GDC-0032 is a potent, and selective inhibitor of Class I PI3-K α, δ, and γ isoforms, with 30-fold less inhibition of the PI3K β isoform relative to the PI3K α isoform. This next generation PI3-K...

    €864 - €2,682
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  • GBR-12935

    Biovision | GBR-12935 | B1998

    GBR-12935 is a potent and selective dopamine reuptake inhibitor.GBR-12935 is a potent and selective dopamine reuptake inhibitor.Biovision | B1998 | GBR-12935 DataSheetAlternate Name/Synonyms: 1-(2...

    €813 - €2,484
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  • Gardiquimod

    Biovision | Gardiquimod | 2002

    A selective ligand for human or mouse Toll-like receptor 7 (TLR7). Induces the activation of NF-κB in HEK 293 cells expressing TLR7. Activates TLR8 only at high concentrations (3µg/ml). Gardiquimod...

    €693 - €1,623
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  • GANT61

    Biovision | GANT61 | 1892

    Cell-permeable. A Hedgehog (Hh) signaling pathway antagonist. Inhibits Hh signaling downstream of Smo and Sufu at the level of Gli (IC₅₀ = 5 µM). GANT61 has also been shown to inhibit the in vitro...

    €1,062 - €179,400
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  • GANT58

    Biovision | GANT58 | 1812

    Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC₅₀ ~ 5 µM in...

    €717 - €2,043
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  • Galloflavin

    Biovision | Galloflavin | 2672

    Galloflavin is a lactate dehydrogenase (LDH) inhibitor inhibiting both LDH-A and LDH-B isoforms of the enzyme with Ki values of 5.46 a µM and 15.06 µM, respectively. It blocks the proliferation of...

    €762 - €2,289
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  • Galiellactone

    Biovision | Galiellactone | 2623

    Galiellalactone is a fungal metabolite that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells (IC₅₀ = 0.25-0.5 μM). The selectivity of this compound is achieved by its ability to...

    €1,107 - €3,666
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  • Fusidic acid

    Biovision | Fusidic acid | B2392

    Fusidic Acid is a bacteriostatic antibiotic derived from the fungus Fusidium coccineum that acts as a bacterial protein synthesis inhibitor by preventing the turnover of elongation factor G (EF-G)...

    €570 - €1,107
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  • Fusicoccin

    Biovision | Fusicoccin | B1625

    Fusicoccin is a toxin originally extracted from Fusicoccum amygdali DelFusicoccin is a toxin originally extracted from Fusicoccum amygdali DelBiovision | B1625 | Fusicoccin DataSheetAlternate...

    €2,091 - €3,564
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  • FURA-5F/AM

    Biovision | FURA-5F/AM | 9551

    FURA-5F/AM is a fluorescent cell membrane-permeant form of FURA-2 (Cat. No. 2243) that can be loaded into the cell where it is hydrolysed by cytosolic esterases and trapped as the active chelator. ...

    €642 - €1,821
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  • FURA-4F/AM

    Biovision | FURA-4F/AM | 9550

    Fura-4F AM is a fluorescent intracellular ratiometric calcium indicator analog of FURA-2 (Cat. No. 2243) for detection of higher Ca²⁺ concentrations. lmax: 370± 3 nm (EtOAc); lem: 475± 4 nm (EtOAc)...

    €615 - €1,599
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  • Fucoxanthine

    Biovision | Fucoxanthine | B2072

    Fucoxanthin is a natural pigment found in microalgae, especially diatoms and Chrysophyta. Recently, it has been shown to have antioxidant, anti-inflammatory, anti-tumor, and anti-obesity activity in...

    €813 - €2,484
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  • FR180204

    Biovision | FR180204 | B1683

    FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 uM and 0.14 uM respectively; has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1...

    €642 - €2,217
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  • FPH2(BRD-9424)

    Biovision | FPH2(BRD-9424) | B2267

    FPH2 (BRD-9424) is a potent promoter of differentiation of iPS-derived hepatocytes. FPH2 induces functional proliferation of hepatocytes in vitro, and thus expands mature human primary hepatocytes...

    €717 - €2,091
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  • Formestane

    Biovision | Formestane | B2041

    Formestane is a steroidal aromatase inhibitor. It binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral...

    €666 - €1,848
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  • FK-866

    Biovision | FK-866 | 1914

    Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an...

    €591 - €1,209
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  • FK-506

    Biovision | FK-506 | 1563

    A potent immunosuppresant and in vitro T cell proliferation blocker. It disrupts calcineurin-mediated signal transduction in T-lymphocytes. It interacts with its FK506-binding protein-12 (FKBP-12),...

    €570 - €1,254
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  • FIPI (free base)

    Biovision | FIPI (free base) | B2372

    FIPI is a potent and selective phospholipase D (PLD) inhibitor. FIPI inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC₅₀ = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell...

    €909 - €2,877
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  • Filipin III

    Biovision | Filipin III | 2744

    Filipin III is a polyene macrolide antibiotic isolated from Streptomyces filipinensis. It may be used in a double staining procedure for the detection of lipoproteins. Binds specifically to...

    €960 - €1,428
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  • FH1 (BRD-K4477)

    Biovision | FH1 (BRD-K4477) | 2732

    FH1 is a small molecule that can enhance the functions of cultured hepatocytes. It enhances differentiation of induced pluripotent stem cells (iPSCs) to hepatocytes and promotes the maturation of...

    €813 - €2,484
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  • FG-4592

    Biovision | FG-4592 | 9681

    FG-4592 is an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase, potentially useful for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription...

    €615 - €1,701
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  • Fexaramate

    Biovision | Fexaramate | 9560

    Fexaramate is a potent, selective, non-steroidal, farnesoid X receptor (FXR) agonist.Fexaramate is a potent, selective, non-steroidal, farnesoid X receptor (FXR) agonist.Biovision | 9560 | Fexaramate...

    €666 - €1,893
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  • FeTPPS

    Biovision | FeTPPS | 2065

    A peroxynitrite decomposition catalyst. An iron porphyrin complex that catalytically isomerizes peroxynitrite to nitrate both in vivo and in vitro thus serving as a decomposition catalyst and a...

    €693 - €1,599
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  • Fatostatin

    Biovision | Fatostatin | 2035

    Cell-permeable. Blocks adipogenesis by inhibiting the activation of SREBPs (Sterol Regulatory Binding Proteins). Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein...

    €729 - €2,043
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