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Biovision

  • CLP-290

    Biovision | CLP-290 | B1282

    CLP-290 is a novel KCC2 (K(+)-Cl(-) cotransporter isoform 2) modulator and prodrug of CLP-257, that is highly selective for KCC2 over related Cl- transporters.CLP-290 is a novel KCC2 (K(+)-Cl(-)...

    $1,120 - $3,584
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  • Cimicoxib

    Biovision | Cimicoxib | B1984

    Cimicoxib is an imidazole derivative and a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent and specific cyclooxygenase-2 (COX-2) inhibitor. Used in veterinary medicine to treat...

    $1,411 - $4,589
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  • CID-755673

    Biovision | CID-755673 | 2660

    CID-755673 is a selective small molecule inhibitor of protein kinase D (PKD) (IC₅₀s = 182, 280, 227 nM for PKD1, 2, and 3, respectively). It exhibits higher selectivity for PKD over Akt, polo-like...

    $837 - $2,440
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  • CID-5951923

    Biovision | CID-5951923 | 2690

    CID-5951923 is an Inhibitor of Krüppel-like factor 5 (KLF5) transcription factor (IC₅₀ = 2.3 μM). Significantly reduces endogenous KLF5 protein levels and decreases viability of colon cancer cells,...

    $837 - $2,440
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  • CID-5721353

    Biovision | CID-5721353 | B1275

    CID-5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor). disrupted BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical site within the BTB groove. This compound...

    $1,292 - $4,190
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  • CID-2011756

    Biovision | CID-2011756 | 2607

    Cell-permeable. CID-2011756 is an ATP-competitive protein kinase D (PKD) inhibitor with IC₅₀ values of 0.6, 0.7 and 3.2 μM for PKD2, PKD3 and PKD1 respectively. Inhibits phorbol ester-induced...

    $837 - $2,440
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  • CID 2745687

    Biovision | CID 2745687 | 1969

    Cell-permeable. A potent, competitive, and reversible antagonist of the orphan receptor GPR35 (Ki = 12.8 nM). Prevents the GPR35-mediated increase in ERK1/2 phosphorylation and β-arrestin recruitment...

    $1,036 - $3,273
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  • CI-994

    Biovision | CI-994 | 1742

    Cell-permeable. A histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100 µM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Displays significant antitumor activity in vitro...

    $749 - $3,570
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  • CHR2797

    Biovision | CHR2797 | 2720

    CHR2797 is a novel metalloenzyme inhibitor. It inhibits proliferation, and induces growth arrest and apoptosis in myeloma cells, including cells resistant to conventional chemotherapeutics.CHR2797 is...

    $1,120 - $3,584
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  • CHIR 99021

    Biovision | CHIR 99021 | 1677

    A potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC₅₀ = 6.7 nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a...

    $1,722 - $19,250
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  • CHD-5

    Biovision | CHD-5 | 2693

    CHD-5 is a potent aryl hydrocarbon receptor (AhR) antagonist.CHD-5 is a potent aryl hydrocarbon receptor (AhR) antagonist.Biovision | 2693 | CHD-5 DataSheetAlternate Name/Synonyms:...

    $837 - $2,440
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  • CH5424802

    Biovision | CH5424802 | 2867

    CH5424802 is a potent, selective, ATP-competitive inhibitor of anaplastic lymphoma kinase (ALK) (IC₅₀ = 1.9 nM). It displays potent antitumor activity against RET-rearranged non-small cell lung...

    $1,120 - $3,584
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  • CGP-57380

    Biovision | CGP-57380 | 9661

    CGP-57380 is a cell-permeable Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC₅₀ = 2.2 μM). Displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases.CGP-57380 is a...

    $837 - $2,440
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  • CGM097

    Biovision | CGM097 | B1820

    CGM097 is a potent and selective MDM2 inhibitor; an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity.CGM097 is a potent and selective MDM2...

    $1,061 - $3,385
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  • CFI-400945

    Biovision | CFI-400945 | B1287

    CFI-400945 is a potent, ATP-competitive inhibitor of PLK4 (Polo-like kinase 4) (Ki = 0.2 nM). Displays anticancer properties. PLK4 inhibition also prevents cell division and inhibits proliferation of...

    $1,292 - $4,732
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  • Cercosporin

    Biovision | Cercosporin | 9684

    Cercosporin is a light-induced polyketide phytotoxin reported to produce singlet oxygen when photoactivated. Acts as a potent and specific PKC inhibitor. Competes for the phorbol binding site...

    $837 - $1,813
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  • Ceralifimod

    Biovision | Ceralifimod | B1289

    Ceralifimod (also known as ONO-4641), is a next-generation sphingosine 1-phosphate (S1P) receptor agonist selective for S1P receptors 1 and 5. In vitro, ONO-4641 displays highly potent agonistic...

    $1,008 - $3,129
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  • CEP-32496

    Biovision | CEP-32496 | 9615

    CEP-32496 specific and selective inhibitor of the activity of the mutated form (V600E) of B-raf kinase. It inhibits the activation of the RAF/mitogen-activated protein kinase kinase...

    $1,120 - $3,584
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  • CEP-18770

    Biovision | CEP-18770 | 2433

    CEP-18770 is a reversible P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome. Displays anti-multimyeloma (MM) effect.CEP-18770 is a reversible P2 threonine...

    $1,411 - $4,851
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  • Celecoxib

    Biovision | Celecoxib | 1574

    Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits prostaglandin production. Celecoxib is approximately 7.6-fold more selective for COX-2 inhibition over COX-1. This specificity...

    $980 - $2,296
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  • Celastrol

    Biovision | Celastrol | 1940

    Cell-permeable. An Antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC₅₀ = 40 nM for IL-1β and IL-1α, 80 nM for IL-6,...

    $665 - $1,694
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  • Cedrulatinib

    Biovision | Cedrulatinib | 2803

    Cerdulatinib is a novel, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. It preferentially inhibits JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in...

    $949 - $2,898
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  • C-DIM 12

    Biovision | C-DIM 12 | B2146

    C-DIM 12 activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Nurr1 is a suppressor of NF-kB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12...

    $777 - $2,209
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  • CCT-245737

    Biovision | CCT-245737 | B2116

    CCT-245737 is a potent and selective checkpoint kinase 1 (Chk1) inhibitor, with an IC₅₀of 1.3 nM; displays weaker activity against Chk2 (IC₅₀of 2440 nM).CCT-245737 is a potent and selective...

    $1,008 - $3,129
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  • CCT-241736

    Biovision | CCT-241736 | B2370

    CCT-241736 is a potent dual FLT3-Aurora inhibitor (IC₅₀ values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively). CCT241736 inhibits a wide range of FLT3 mutants, including...

    $949 - $2,898
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  • CCT-137690

    Biovision | CCT-137690 | B1935

    CCT137690 is a highly selective and orally bioavailable inhibitor of Aurora A, Aurora B and Aurora C with IC₅₀ of 15 nM, 25 nM and 19 nM, respectively. Displays anti-tumor activities both in vitro...

    $1,008 - $3,129
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  • CCT-129202

    Biovision | CCT-129202 | B1934

    CCT-129202 is a potent, ATP-competitive inhibitor of Aurora kinases with IC₅₀ values of 42 nM, 198 nM and 227 nM for Aurora A, B and C, respectively. CCT-129202 displays high selectivity for the...

    $777 - $2,209
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  • CCF-642

    Biovision | CCF-642 | B2009

    CCF-642 is a protein disulfide isomerase (PDI) inhibitor that displays anticancer activity in multiple myeloma. Consistent with PDI inhibition, CCF642 causes acute ER stress in multiple myeloma cells...

    $1,008 - $3,129
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  • CC-122

    Biovision | CC-122 | B1650

    CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity.CC-122 binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL.CC-122...

    $1,635 - $5,075
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  • CBL0137

    Biovision | CBL0137 | B2036

    CBL0137 is a metabolically stable curaxin that activates p53 (EC₅₀ = 0.37 μM) and inhibits NF-κB (EC₅₀ = 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT),...

    $1,061 - $3,357
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  • CBHA

    Biovision | CBHA | 2284

    A potent histone deacetylase (HDAC) inhibitor (ID₅₀ values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively). CBHA also induces apoptosis in nine different neuroblastoma cell lines in...

    $889 - $1,411
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  • CB-839

    Biovision | CB-839 | B1179

    CB-839 is a potent, selective, and orally bioavailable inhibitor of both splice variants of glutaminase (KGA and GAC); inhibits recombinant GAC with an IC₅₀ of

    $1,239 - $4,018
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  • CB5083

    Biovision | CB5083 | B1032

    CB5083 is a potent, ATP-competitive, D2-selective, p97 inhibitor (IC₅₀ = 11 nM). In xenograft models, CB-5083 causes modulation of key p97-related pathways, induces apoptosis, and has antitumor...

    $1,008 - $3,129
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