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Biovision

  • (−)-Huperzine A

    Biovision | (−)-Huperzine A | B3095

    (−)-Huperzine A is a potent and reversible inhibitor of acetylcholinesterase. It shows an IC₅₀ value of 82 nM against acetylcholinesterase in the rat cortex in vitro. It also acts as an antagonist of...

    $665 - $1,782
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  • Metergoline

    Biovision | Metergoline | B3088

    Metergoline is a serotonin (5-HT) receptor antagonist. It is active at 5-HT1 (pKi=7.8 for 5-HT1B), 5-HT2 (pKi=8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C respectively) and 5-HT7 (pKi=16 nM)...

    $637 - $1,666
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  • Elbasvir

    Biovision | Elbasvir | B3087

    Elbasvir is a potent inhibitor of Hepatitis C virus (HCV), non-structural protein 5A (NS5A). It is active against many HCV genotypes with EC₅₀ values in the picomolar range (0.0003 nM-3.4 nM). It is...

    $777 - $2,237
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  • Darunavir

    Biovision | Darunavir | B3086

    Darunavir is an HIV-1 protease inhibitor with an IC₅₀ of 3 nM and cytoxicity of 74.4 μM. It is also also active against wild-type and multidrug-resistant clinical isolates of HIV-1 in...

    $637 - $1,666
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  • Trabectedin

    Biovision | Trabectedin | B3084

    Trabectedin is a natural product originally isolated from the sea squirt, Ecteinascidia turbinata and is currently prepared synthetically. It interferes with transcription factors, DNA‐binding...

    $2,268 - $6,570
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  • BIBR-1532

    Biovision | BIBR-1532 | B3082

    BIBR-1532 is a highly potent mixed-type non-competitive inhibitor of telomerase. It inhibits telomerase in a dose-dependent manner, with an IC₅₀ of 93 nM. It specifically targets the telomerase...

    $889 - $2,699
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  • (-)-Equol

    Biovision | (-)-Equol | B3081

    S-equol is a metabolite of soy isoflavonoid phytoestrogen daidzein, produced by human intestinal bacteria. S-equol has a high affinity for estrogen receptor beta (ERβ) than estrogen receptor (ERα)...

    $718 - $1,985
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  • GRL-0617

    Biovision | GRL-0617 | B3079

    GRL-0617 is a potent inhibitor of the papain-like protease (PLpro) from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro cleaves the viral polyproteins. GRL-0617...

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  • Mapracorat

    Biovision | Mapracorat | B3078

    Mapracorat is a selective glucocorticoid receptor agonist (SEGRA) with anti-inflammatory properties. It is in clinical trials for the topical treatment of atopic dermatitis, allergic conjunctivitis...

    $837 - $2,468
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  • Sarecycline

    Biovision | Sarecycline | B3077

    Sarecycline is a semi-synthetic tetracycline, narrow-spectrum antibiotic, being developed to treat patients suffering from moderate to severe acne vulgaris. Sarecycline is more active than...

    $809 - $2,356
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  • GS-441524

    Biovision | GS-441524 | B3076

    GS-441524 is the predominant metabolite of remdesivir in blood and is the nucleoside of the prodrug remdesivir. It is phosphorylated to the active triphosphate metabolite which incorporates into RNA...

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  • ONC-201

    Biovision | ONC-201 | B3075

    ONC-201 is an orally active transcriptional inducer of Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL). It induces TRAIL in a p53-independent manner at concentrations of 1.25 μM-5 μM...

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  • (S)-Crizotinib

    Biovision | (S)-Crizotinib | B3071

    (S)-crizotinib is a low nanomolar inhibitor of 7,8-dihydro-8-oxoguanine triphosphatase (MTH1 or NUDT1) whereas the (R)-enantiomer shows IC₅₀ values in the micromolar range. MTH1 aids in...

    $1,092 - $3,616
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  • Golgicide A

    Biovision | Golgicide A | B3070

    ADP-ribosylation factor 1 (Arf1) plays an important role in regulating secretory traffic and membrane transport within the Golgi. Arf1 is activated by guanine nucleotide exchange factors (ArfGEFs)...

    $1,092 - $3,504
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  • CHIR-124

    Biovision | CHIR-124 | B3069

    CHIR-124 is a quinolone-based inhibitor of Checkpoint kinase-1 (Chk1). It potently and selectively inhibits Chk1 in vitro with an IC₅₀ of 0.3 nM. It interacts synergistically with topoisomerase...

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  • Riluzole

    Biovision | Riluzole | B3068

    Riluzole is a benzothiazole derivative which inhibits glutamatergic neurotransmission and blocks voltage-dependent sodium channels (ED₅₀ = 2.3 μM). It reduces the uptake of GABA from neuronal synapse...

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  • LDN-193189

    Biovision | LDN-193189 | B3067

    LDN-193189 inhibits the activity of the Bone Morphogenetic Protein (BMP) type I receptors ALK2 and ALK3 with IC₅₀ values of 5 nM and 30 nM respectively and shows weaker effects on activin and the...

    $1,120 - $3,129
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  • GSA 10

    Biovision | GSA 10 | B3065

    GSA 10 is a novel, potent activator of the smoothened receptor (Smo). GSA 10 acts at Smo and promotes the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC₅₀ = 1.2 µM)...

    $1,292 - $4,277
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  • JTE-607

    Biovision | JTE-607 | B3064

    JTE-607 is a multiple cytokine inhibitor. It inhibits cytokine production specifically in human peripheral blood mononuclear cells without causing immunosuppression. It inhibits tumor necrosis...

    $1,008 - $3,129
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  • R-7050

    Biovision | R-7050 | B3063

    R-7050 is a cell-permeable inhibitor of signaling through the TNFα receptor (TNFαR) complex. It blocks the formation of signal-initiating complexes that consist of TNFα receptor (TNFαR) I, TNFαR...

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  • C87

    Biovision | C87 | B3062

    C87 is an inhibitor of Tumor Necrosis Factor α (TNFα). It binds to human TNFα with a KD of 110 nM and potently inhibits TNFα-induced cytotoxicity in L929 cells with an IC₅₀ of 8.73 μM. It effectively...

    $1,208 - $3,959
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  • BAY-678

    Biovision | BAY-678 | B3061

    BAY-678 is a potent, selective, cell-permeable inhibitor of human neutrophil elastase (HNE).The activity of HNE is increased in inflammatory diseases. BAY-678 shows Ki values of 15 nM and 600 nM for...

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  • BAY-677

    Biovision | BAY-677 | B3060

    BAY-677 is a negative control for BAY-678. BAY-678 is a potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE) with an IC₅₀ of 20 nM. The S-enantiomer BAY-677 inhibits HNE...

    $1,323 - $4,389
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  • Tucidinostat

    Biovision | Tucidinostat | B3059

    Tucidinostat is an inhibitor of histone deacetylases (HDACs) with IC₅₀ values of 95 nM, 160 nM, 67 nM and 78 nM for HDAC1, HDAC2, HDAC3 and HDAC10 respectively. It shows potent antitumor activity. It...

    $809 - $2,356
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  • E-64d

    Biovision | E-64d | B3057

    E-64d is a synthetic analog of E-64 which is a membrane permeable inhibitor of lysosomal and cytosolic cysteine proteases. It inhibits cathepsins B and L in intact lysosomes and cells. It (20-200...

    $1,061 - $3,357
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  • Prazosin

    Biovision | Prazosin | B3055

    Prazosin is an antagonist of α1-adrenergic receptors (α1-ARs). The affinity estimates (pKi) for inhibition of [3H]-prazosin binding to CHO-K1 cells expressing cloned human α1A, α1B and α1D...

    $637 - $1,635
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  • FITC-Tyramide

    Biovision | FITC-Tyramide | B3054

    Tyramide signal amplification is an enzyme-catalyzed deposition of tyramide on or near a protein or nucleic acid in situ. The enzyme horseradish peroxidase (HRP) converts the labelled tyramide...

    $1,292 - $1,985
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  • Siramesine

    Biovision | Siramesine | B3053

    Siramesine is an agonist for sigma-2 (σ2) receptor. It is selective for σ2 over σ1 with IC₅₀ values of 0.12 nM and 17 nM respectively. It shows potent anxiolytic-like effects in rodents. The minimal...

    $777 - $2,209
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  • Omeprazole

    Biovision | Omeprazole | B3052

    Omeprazole is a proton pump inhibitor (PPI). It inhibits gastric H+/K+ ATPase with an IC₅₀ of 1.1 μM. It shows competitive inhibition of cytochrome P450 enzyme CYP2C19 activity with a Ki of 2-6 μM...

    $637 - $889
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  • RIPA-56

    Biovision | RIPA-56 | B3051

    RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with an IC₅₀ of 13 nM. It protects HT-29 cells against TNFα-induced...

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  • Astemizole

    Biovision | Astemizole | B3050

    Astemizole is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM. Astemizole also shows potent hERG potassium channel blocking activity with an IC₅₀ of 0.9 nM. Astemizole shows synergistic...

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  • S1RA (E-52862)

    Biovision | S1RA (E-52862) | B3048

    S1RA is a highly selective sigma-1 (σ1) receptor antagonist. It shows high affinity for σ1 receptors with Ki values of 17 nM and 23.5 nM for human and guinea pig σ1 receptors respectively but no...

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  • Pridopidine

    Biovision | Pridopidine | B3045

    Pridopidine is a phenylpiperidine dopaminergic stabilizer. It is a low affinity dopamine D2 receptor antagonist and a potent sigma-1 receptor (S1R) agonist. The affinity of pridopidine for S1R is...

    $637 - $1,411
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