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Product Description
Anti-Human CD45RO Monoclonal Antibody (AF647 Conjugated) | DL21727F | DLdevelop
Host: Mouse
Synonyms: N/A
Reactivity: Human
Application: FCM
Background: CD45RO is a 180 kD single chain membrane glycoprotein. It is a splice variant of tyrosine phosphatase CD45, lacking the A, B, and C determinants. The CD45RO isoform is expressed on activated and memory T cells, some B cell subsets, activated monocytes/macrophages, and granulocytes. CD45RO enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1 and CD22. CD45 isoform expression can change in response to cytokines.
Concentration: N/A
Conjugation: AF647
Buffer: PBS with 0.05% Proclin300, 1% BSA
Clone: UCHL1
Isotype: Mouse IgG2a, κ
