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Product Description
Anti-Mouse CD54 Monoclonal Antibody (PE/Cyanine5.5 Conjugated) | DL20358F | DLdevelop
Host: Rat
Synonyms: Intercellular adhesion molecule 1, Icam1, MALA-2, MyD10, CD54, Icam-1
Reactivity: Mouse
Application: FCM
Background: CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) . CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.
Concentration: 0.2 mg/mL
Conjugation: PE/Cyanine5.5
Buffer: PBS with 0.05% Proclin300, 1% BSA
Clone: YN1/1.7.4
Isotype: Rat IgG2b, κ
