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Product Description
Purified Anti-Human CD279/PD-1 Monoclonal Antibody | DL22250F | DLdevelop
Host: Mouse
Synonyms: PDCD1, PD1, Protein PD-1, hPD-1
Reactivity: Human
Application: FCM, IHC
Background: Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
Concentration: 0.2 mg/mL
Conjugation: Unconjugated
Buffer: PBS with 0.05% Proclin300
Clone: J110
Isotype: Mouse IgG1, κ
![Purified Anti-Human CD279/PD-1 Antibody[J116]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/438258/640640/elabscience__13538.1643193164__44410.1643194172__66892.1647344407.png?c=2 "Purified Anti-Human CD279/PD-1 Antibody[J116]")