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Product Description
DUSP3 Polyclonal Antibody | E-AB-65870 | Elabscience
Type: Polyclonal Antibody
Synonyms: DUSP3, VHR
Application: WB
Reactivity: Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Metabolism, Signal Transduction
Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant fusion protein of human DUSP3 (NP_004081.1).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification Method: Affinity purification
Dilution: WB 1:500-1:1000
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 16 kDa/20 kDa
Molecular Weight(Observed): 20 kDa
