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Product Description
GRM1 Polyclonal Antibody | E-AB-63478 | Elabscience
Type: Polyclonal Antibody
Synonyms: GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13
Application: WB
Reactivity: Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Neuroscience
Background: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant fusion protein of human GRM1 (NP_001264993.1).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 101 kDa/132 kDa
Molecular Weight(Observed): 132 kDa
