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Product Description
HSP40-4 Polyclonal Antibody | E-AB-11313 | Elabscience
Type: Polyclonal Antibody
Synonyms: DJ 2, DJ2, DjA1, DnaJ (Hsp40) homolog, subfamily A, member 1, DnaJ homolog subfamily A member 1, DnaJ protein homolog 2, DNAJ2, Dnaja1, DNJA1, hDJ 2, HDJ-2, HDJ2, Heat shock 40 kDa protein 4, heat shock protein DNAJ like 2, Heat shock protein J2, HSDJ, HSJ-2, HSJ2, HSPF4, Human DnaJ protein 2, NEDD7, Neural precursor cell expressed developmentally down regulated 7, OTTHUMP00000021193
Application: WB, IHC, ELISA
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Signal Transduction
Background: DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
Concentration: 0.5 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant protein of human DNAJA1
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000, IHC 1:100-1:300
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 45 kDa
Molecular Weight(Observed): N/A
