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Product Description
EV450 Anti-Human CD8a Antibody[OKT-8] | E-AB-F1110Q | Elabscience
Category: Flow Cytometry Antibody
Synonyms: T-cell surface glycoprotein CD8 alpha chain,CD8A,T-lymphocyte differentiation antigen T8/Leu-2,MAL
Swissprot Code: P01732
Application: FCM
Reactivity: Human
Host: Mouse
Isotype: Mouse IgG2a, κ
Reaserch Area: N/A
Background: CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Concentration: N/A
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Immunogen: N/A
Purification Method: N/A
Dilution: N/A
Clone: OKT-8
Conjugation: EV450
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