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Product Description
RYR2 Polyclonal Antibody | E-AB-32840 | Elabscience
Type: Polyclonal Antibody
Synonyms: ARVC2, ARVD2, Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, hRYR-2, ryanodine receptor 2 (cardiac), Ryanodine receptor 2, RyR, RYR-2, RyR2, RYR2, Type 2 ryanodine receptor, VTSIP
Application: WB, IHC-p, IF, ELISA
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction
Background: This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.RYR2 (Ryanodine Receptor 2) is a Protein Coding gene. Diseases associated with RYR2 include Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 and Arrhythmogenic Right Ventricular Dysplasia 2. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cell-type Dependent Selectivity of CCK2R Signaling. GO annotations related to this gene include calcium ion binding and protein kinase binding. An important paralog of this gene is RYR3.
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthesized peptide derived from human RyR-2 around the non-phosphorylation site of Ser2808.
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 564 kDa
Molecular Weight(Observed): 200-300 kDa
