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Product Description
AKT1 Monoclonal Antibody | E-AB-22210 | Elabscience
Type: Monoclonal Antibody
Synonyms: AKT 1, AKT, AKT1, AKT1, MGC99656, PKB, PKB-ALPHA, PRKBA, Protein Kinase B Alpha, Protein kinase B, Proto-oncogene c-Akt, RAC Alpha, RAC, RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha
Application: WB, IHC-p
Reactivity: Human
Host: Mouse
Isotype: IgG
Reserch Areas: Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction
Background: The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic Peptide of AKT1
Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification Method: Protein A purification
Dilution: WB 1:1000-2000, IHC 1:100-200
Clone: Clone:10D6
Conjugation: Unconjugated
Molecular Weight(Calculated): N/A
Molecular Weight(Observed): 60 kDa
