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Product Description
Phospho-p53(S33) Polyclonal Antibody | E-AB-68200 | Elabscience
Type: Phosphorylated antibody
Synonyms: BCC7, LFS1, P53, TRP53, p53, TP53, BMFS5
Application: WB, IHC
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Reserch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Background: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: A synthetic phosphorylated peptide around S33 of human p53 (NP_000537.3).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification Method: Affinity purification
Dilution: WB 1:500-1:2000 IHC 1:50-1:100
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): 23-43 kDa
Molecular Weight(Observed): 55 kDa
