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Product Description
B7-H3/CD276 | E21-K62 | EnoGene
Short Description: Recombinant Human B7 Homolog 3 is produced by our Mammalian expression system and the target gene encoding Leu29-Thr461 is expressed with a 6His tag at the C-terminus.
Shipping: Ambient
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg /ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Background: CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.
Species: Human
Expression System: Human cells
![CD276 [B7-H3] Recombinant Protein](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/599175/850549/porsci_lo__79508.1648973713__16731.1649084691__47141.1649158903__38788.1649163908.png?c=2 "CD276 [B7-H3] Recombinant Protein")
![CD276 [B7-H3] Recombinant Protein](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/599176/850550/porsci_lo__79508.1648973713__16731.1649084691__47141.1649158903__78958.1649163908.png?c=2 "CD276 [B7-H3] Recombinant Protein")
![CD276 [B7-H3] Recombinant Protein](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/599174/850548/porsci_lo__79508.1648973713__16731.1649084691__47141.1649158903__91134.1649163908.png?c=2 "CD276 [B7-H3] Recombinant Protein")
