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Product Description
Anti- MDC1 Antibody | FNab05072 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Immunogen: mediator of DNA damage checkpoint 1
synonyms: KIAA0170, NFBD1
Molecular weight (observed) : 270 kDa
Reactivity Species: Human
Tested Application: ELISA, WB
Recomended Dillution : WB: 1:500 - 1:2000; IHC: 1:100 - 1:200
Research Area: Epigenetics, Metabolism
