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Product Description
Anti- PSMD14 Antibody | FNab06886 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs) : acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Immunogen: proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
synonyms: PAD1, POH1, PSMD14, rpn11
Molecular weight (observed) : 35 kDa
Reactivity Species: Human
Tested Application: ELISA, WB, IHC, IF
Recomended Dillution : WB: 1:200-1:2000; IHC: 1:20-1:200
Research Area: Metabolism
