Euro
USD
British Pound
NULL
Product Description
Anti- CEP152 Antibody | FNab01597 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806) . Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615) . Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597) . Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity) . Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615) .
Immunogen: centrosomal protein 152kDa
synonyms: KIAA0912
Molecular weight (observed) : 110 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, WB
Recomended Dillution : WB: 1:500-1:2000; IP: 1:200-1:1000
Research Area: Cell Division, Proliferation, Epigenetics
