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Product Description
Anti- DKK2 Antibody | FNab02402 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) .
Immunogen: dickkopf homolog 2
synonyms: Dickkopf 2, Dickkopf related protein 2, DKK 2, DKK2, hDkk 2
Molecular weight (observed) : 32 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IF, IHC
Recomended Dillution : WB: 1:500-1:1000; IHC: 1:20-1:200
Research Area: Developmental biology
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