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Product Description
Anti- ATG12 Antibody | FNab10376 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Immunogen: ATG12 autophagy related 12 homolog (S. cerevisiae)
synonyms: APG12, APG12L
Molecular weight (observed) : 48-50kd
Reactivity Species: Human, Mouse
Tested Application: ELISA, WB, IHC
Recomended Dillution : IHC: 1:50-1:200
Research Area: Epigenetics, Immunology, Cardiovascular, Metabolism
