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Product Description
Anti- USP16 Antibody | FNab09312 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B-and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
Immunogen: ubiquitin specific peptidase 16
synonyms: Deubiquitinating enzyme 16, Ubiquitin thiolesterase 16, UBP M, USP16
Molecular weight (observed) : 94 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IP
Recomended Dillution : WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200
Research Area: Epigenetics, Metabolism
