Product Description
Anti- APP Antibody | FNab00513 | FineTest
Form: liquid
Purification: Protein A+G purification
Purity: ≥95% as determined by SDS-PAGE
Host: Mouse
Clonality: monoclonal
Clone ID: 8B9
Isotype: IgG2a
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu (2+) and Fe (3+) to Cu (+) and Fe (2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts. The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
Immunogen: amyloid beta A4 precursor protein
synonyms: A4, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Beta-amyloid precursor protein, CVAP, PreA4
Molecular weight (observed) : 100 kDa
Reactivity Species: Human, Pig
Tested Application: ELISA, WB, IHC
Recomended Dillution : WB: 1:500-1:2000; IHC: 1:50-1:500
Research Area: Neuroscience, Signal Transduction, Metabolism