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Product Description
Anti- RENALASE Antibody | FNab07239 | FineTest
Form: liquid
Purification: Protein A+G purification
Purity: ≥95% as determined by SDS-PAGE
Host: Mouse
Clonality: monoclonal
Clone ID: 9C9
Isotype: IgG1
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity. (PMID:15841207) This antibody is specific to RNLS.
Immunogen: chromosome 10 open reading frame 59
synonyms: C10orf59, MAO C, Monoamine oxidase C, RENALASE, RNLS
Molecular weight (observed) : 38 kDa
Reactivity Species: Human
Tested Application: ELISA, WB, IHC, IP
Recomended Dillution : WB: 1:500-1:3000; IHC: 1:20-1:200
Research Area: Cardiovascular, Metabolism
