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Product Description
Anti- Zyxin Antibody | FNab09765 | FineTest
Form: liquid
Purification: Protein A+G purification
Purity: ≥95% as determined by SDS-PAGE
Host: Mouse
Clonality: monoclonal
Clone ID: 8D5
Isotype: IgG1
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin (ZYX) is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles.
Immunogen: zyxin
synonyms: ESP 2, HED 2, ZYX, zyxin, Zyxin 2
Molecular weight (observed) : 80 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, WB
Recomended Dillution : WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200
Research Area: Cell Division and Proliferation, Signal Transduction
