Product Description
Anti- KHDRBS3 Antibody | FNab04523 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly (A) . RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068) . Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763) . In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity) . Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068) . Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity) . May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity) . Can bind FABP9 mRNA (By similarity) . May play a role as a negative regulator of cell growth. Inhibits cell proliferation. (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression.
Immunogen: KH domain containing, RNA binding, signal transduction associated 3
synonyms: SALP, SLM2
Molecular weight (observed) : 55 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IF
Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200
Research Area: Metabolism, Developmental biology