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Product Description
Anti- ECD Antibody | FNab10368 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345) . May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932) . Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839) . The cell cycle-regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270) . May play a role in regulation of pre-mRNA splicing (PubMed:24722212) .
Immunogen: ecdysoneless homolog (Drosophila)
synonyms: ECD, GCR2, HSGT1, Protein ecdysoneless homolog, Protein SGT1, SGT1, Suppressor of GCR2
Molecular weight (observed) : 70-100 kDa
Reactivity Species: Human
Tested Application: ELISA, WB
Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200
Research Area: Metabolism
