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Product Description
Anti- TSHZ3 Antibody | FNab09046 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site (s) . Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.
Immunogen: teashirt zinc finger homeobox 3
synonyms: FLJ54422, KIAA1474, Teashirt homolog 3, TSH3, TSHZ3, Zinc finger protein 537, ZNF537
Molecular weight (observed) : 110 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, WB, IHC, IF
Recomended Dillution : WB: 1:200-1:2000
Research Area: Metabolism, Developmental biology
