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Product Description
Anti- PTPN22 Antibody | FNab06936 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643) . Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704) . Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343) . Dephosphorylates the immune system activator SKAP2 (PubMed:21719704) . Positively regulates toll-like receptor (TLR) -induced type 1 interferon production (PubMed:23871208) . Promotes host antiviral responses mediated by type 1 interferon (By similarity) . Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106) .
Immunogen: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
synonyms: PTPN8
Molecular weight (observed) : 79-95 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IF
Recomended Dillution : WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Research Area: Signal Transduction, Metabolism
