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Product Description
Anti- SNX27 Antibody | FNab08090 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns (3P) ) . May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
Immunogen: sorting nexin family member 27
synonyms: KIAA0488
Molecular weight (observed) : 52-60 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB
Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200
Research Area: Signal Transduction
![SNX27 Antibody (Center) [AMM07919G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/869005/1161072/logo__92149.1659788186__72414.1659865294.png?c=2 "SNX27 Antibody (Center) [AMM07919G]"){kind=logo}
