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Product Description
Anti- REST Antibody | FNab07244 | FineTest
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.
Immunogen: RE1-silencing transcription factor
synonyms: NRSF, REST, X2 box repressor, XBR
Molecular weight (observed) : 122 kDa, 200kd
Reactivity Species: Human, Rat
Tested Application: ELISA, WB, IHC
Recomended Dillution : WB: 1:500-1:1000; IP: 1:500-1:2000
Research Area: Stem Cells, Metabolism
