Antibodies that detect CD33 can be used in several scientific applications, including Flow Cytometry, Western Blot, Immunocytochemistry, Immunohistochemistry (Paraffin) and ELISA. These antibodies target CD33 in Human, Mouse, Non-human primate and Rat samples.
Our CD33 monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit and Rat. These antibodies have been verified by Cell treatment and Knockout to confirm specificity to CD33. Find the CD33 antibody that fits your needs. Choose from 1 of 108 CD33 antibodies, which have been validated in experiments with 148 publications and 279 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.
Target Information
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.
Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is also expressed on, and is a useful marker for, peripheral monocytes. CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
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