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  • Anti-TREM-2 Antibody Mouse Anti-Human

    • Anti-TREM-2 Antibody Mouse Anti-Human | 544-MBS692386

    NULL340.00

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    SKU:
    544-MBS692386
    Availability:
    IN STOCK
    Size:
    100 µL
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    Product Description

    Anti-TREM-2 Antibody Mouse Anti-Human | 544-MBS692386

    Quality Level

    100

    biological source

    rat

    antibody form

    purified antibody

    antibody product type

    primary antibodies

    clone

    78, monoclonal

    species reactivity

    human, mouse, rat

    technique(s)

    flow cytometry: suitable
    immunocytochemistry: suitable
    immunoprecipitation (IP): suitable
    inhibition assay: suitable
    western blot: suitable

    isotype

    IgG1κ

    NCBI accession no.

    NP_001259007

    UniProt accession no.

    Q99NH8

    General description

    TREM-2, also known as Triggering receptor expressed on myeloid cells 2 or Triggering receptor expressed on monocytes 2, and encoded by the gene Trem2/Trem2a/Trem2b/Trem2c, is a protein that forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
     
    TREM-2 may also have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM-2 is localized to the cell membrane and is a single pass membrane protein. TREM-2 is expressed in immune cells such as microglia and monocytes but the expression varies depending upon the exact tissue and location within the tissue. Defects in TREM-2 may be associated in humans with frontotemporal dementia, Nasu-Hakola disease, and recently an increase risk of Alzheimer′s disease.

    Specificity

    This antibody does not cross react with mouse TREM-1 or TREM-3 (Prof. William Seaman, University of California, San Francisco.).

    Immunogen

    Recombinant protein corresponding to mouse TREM-2.

    Application

    Research Category
    Neuroscience
    This Anti-TREM-2 Antibody, clone 78 is validated for use in western blotting, ICC, flow cytometry, inhibition & IP for the detection of TREM-2.
    Immunocytochemistry Analysis: A representative lot from an independent laboratory detected TREM-2 in TRACP+ osteoclasts (Humprey, M. B., et al. (2006). J Bone Miner Res. 21(2):237-245.).

    Flow Cytometry Analysis: A representative lot from an independent laboratory detected TREM-2 in RAW264.7 cells (Humprey, M. B., et al. (2006). J Bone Miner Res. 21(2):237-245.).

    Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated TREM-2 from mouse macrophage lysates (Peng, Q., et al. (2010). Sci Signal. 3(122):ra38.).

    Inhibition Analysis: : Pre-treatment of BV2 cells or C57BL/6 Osteoclasts with a representative lot of this antibody significantly reduces cellular activation in response to both untreated and apoptotic Neuro2A cells (Hsieh, C. L., et al. (2009). J Neurochem. (109):4:1144-1156.; Humprey, M. B., et al. (2006). J Bone Miner Res. 21(2):237-245).

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