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![Phospho-JMJD2A (Y547) Antibody [APR32065G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/872310/1164377/logo__92149.1659788186__07779.1659868420.png?c=2 "Phospho-JMJD2A (Y547) Antibody [APR32065G]"){kind=logo}
![Phospho-JMJD2A (Y547) Antibody [APR32065G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/872310/1164377/logo__92149.1659788186__07779.1659868420.png?c=2 "Phospho-JMJD2A (Y547) Antibody [APR32065G]"){kind=logo}
Product Description
Phospho-JMJD2A (Y547) Antibody [APR32065G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This JMJD2A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y547 of human JMJD2A.
Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16024779}
Molecular Weight: 120662
Clone: Polyclonal
Gene Name: KDM4A
Gene ID: 9682
Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168) . Does not demethylate histone H3 'Lys- 4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
Summary: Tissue Location: Ubiquitous..
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: DB
Dilution: DB--1:500
Synonyms: Lysine-specific demethylase 4A, 11411-, JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A, KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
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