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![Phospho-MAP4K1 (Y381) Antibody [AMM07147G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/866987/1159054/logo__92149.1659788186__65642.1659863452.png?c=2 "Phospho-MAP4K1 (Y381) Antibody [AMM07147G]"){kind=logo}
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Product Description
Phospho-MAP4K1 (Y381) Antibody [AMM07147G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This MAP4K1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y381 of human MAP4K1.
Cellular Localisation: N/A
Molecular Weight: 91296
Clone: Polyclonal
Gene Name: MAP4K1
Gene ID: 11184
Function: Serine/threonine-protein kinase, which may play a role in the response to environmental stress (PubMed:24362026) . Appears to act upstream of the JUN N-terminal pathway (PubMed:8824585) . May play a role in hematopoietic lineage decisions and growth regulation (PubMed:8824585, PubMed:24362026) . Able to autophosphorylate (PubMed:8824585) . Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (By similarity) .
Summary: Tissue Location: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: DB
Dilution: DB--1:500
Synonyms: Mitogen-activated protein kinase kinase kinase kinase 1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, MAP4K1, HPK1
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