Product Description
Phospho-rat BAD (S97) Antibody [APR32073G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: Rat
Specificity: This rat BAD Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S97 of rat BAD.
Cellular Localisation: Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm. Upon phosphorylation, locates to the cytoplasm {ECO:0000250|UniProtKB:Q61337}
Molecular Weight: 22228
Clone: Polyclonal
Gene Name: Bad
Gene ID: 64639
Function: Promotes cell death. Successfully competes for the binding to Bcl-X (L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X (L), but not that of Bcl-2 (By similarity) . Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Summary: Tissue Location: Expressed in all tissues tested, including brain, liver, spleen and heart. In the brain, restricted to epithelial cells of the choroid plexus. Isoform alpha is the more abundant form
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: DB
Dilution: DB--1:500
Synonyms: Bcl2-associated agonist of cell death, BAD, Bcl-2-binding component 6, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, Bad