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![Phospho-SOX2 (S83) Antibody [APR12845G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/867085/1159152/logo__92149.1659788186__83763.1659863492.png?c=2 "Phospho-SOX2 (S83) Antibody [APR12845G]"){kind=logo}
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Product Description
Phospho-SOX2 (S83) Antibody [APR12845G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This SOX2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S83 of human SOX2.
Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:P48432}.
Molecular Weight: 34310
Clone: Polyclonal
Gene Name: SOX2
Gene ID: 6657
Function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity) . Binds to the proximal enhancer region of NANOG (By similarity) . Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408) . Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity) . Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) . May function as a switch in neuronal development (By similarity) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: DB
Dilution: DB--1:500
Synonyms: Transcription factor SOX-2, SOX2
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