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![Phospho-Wee1 (S123) Antibody [APR05159G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/866957/1159024/logo__92149.1659788186__03356.1659863440.png?c=2 "Phospho-Wee1 (S123) Antibody [APR05159G]"){kind=logo}
![Phospho-Wee1 (S123) Antibody [APR05159G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/866957/1159024/logo__92149.1659788186__03356.1659863440.png?c=2 "Phospho-Wee1 (S123) Antibody [APR05159G]"){kind=logo}
Product Description
Phospho-Wee1 (S123) Antibody [APR05159G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This Wee1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S123 of human Wee1.
Cellular Localisation: Nucleus.
Molecular Weight: 71597
Clone: Polyclonal
Gene Name: WEE1
Gene ID: 7465
Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: DB, IHC-P
Dilution: DB--1:500 IHC-P--1:100~500
Synonyms: Wee1-like protein kinase, WEE1hu, Wee1A kinase, WEE1
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