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Product Description
RARA Antibody (C-term) [APR31166G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This RARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-349 amino acids from the C-terminal region of human RARA.
Cellular Localisation: Nucleus. Cytoplasm. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation (PubMed:19850744) Translocation to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation (By similarity) . Increased nuclear localization upon pulsatile shear stress (PubMed:28167758) . {ECO:0000250|UniProtKB:P11416, ECO:0000269|PubMed:19850744, ECO:0000269|PubMed:28167758}
Molecular Weight: 50771
Clone: Polyclonal
Gene Name: RARA
Gene ID: 5914
Function: Receptor for retinoic acid (PubMed:19850744, PubMed:16417524, PubMed:20215566) . Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9- cis retinoic acid, and regulate gene expression in various biological processes (PubMed:28167758) . The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:28167758) . In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524) . On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:9267036, PubMed:19850744, PubMed:20215566) . Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758) . Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758) . RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity) . Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity) . In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity) . In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity) . Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758) . In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758) .
Summary: Tissue Location: Expressed in monocytes.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IF, IHC-P, FC, WB
Dilution: WB--1:1000 IF--1:10~50 IHC-P--1:100~500 FC--1:10~50
Synonyms: Retinoic acid receptor alpha, RAR-alpha, Nuclear receptor subfamily 1 group B member 1, RARA, NR1B1
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