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Product Description
SOX2 Antibody (Center) [APR13460G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This SOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-119 amino acids from the Central region of human SOX2.
Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:P48432}.
Molecular Weight: 34310
Clone: Polyclonal
Gene Name: SOX2
Gene ID: 6657
Function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity) . Binds to the proximal enhancer region of NANOG (By similarity) . Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408) . Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity) . Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) . May function as a switch in neuronal development (By similarity) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IF, FC, WB
Dilution: WB--1:4000 IF--1:10~50 FC--1:10~50
Synonyms: Transcription factor SOX-2, SOX2
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